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Questions and discussion to help forum members determine if they may have multiple myeloma, smoldering multiple myeloma, or MGUS.

Can you have myeloma & normal WBC, calcium & platelets?

by JeanW on Sat Mar 26, 2016 7:49 pm

Hi everyone,

I am new to this forum. I have many of the symptoms of myeloma and believe the doctor thinks it is a good possibly I will be diagnosed soon based on symptoms and my specific protein analysis showing Alpha 2 Percent being high at 13.6 and Alpha 2 Glob being 1.03 (high). I am now waiting on results of a serum immunofixation and quantitative immunoglobulins test.

My question is: Can you have myeloma if WBC, calcium, and platelets are within normal range?

Just scared. Thank you for listening.

JeanW

Re: Can you have myeloma & normal WBC, calcium & platelets?

by Aclinkboca on Sun Mar 27, 2016 12:01 am

JeanW,

I understand how you feel. I was diagnosed in December and I my labs were perfectly normal. I had and still don't have any M-spike and all my labs are normal, but I have kappa light chain multiple myeloma and my kappa free light chain numbers when diagnosed where over 1000. I am thankful I have normal labs and all my kidney and liver functions are good as I have gone through my chemo and induction therapy.

I wish you the best of luck.

AC

Aclinkboca
Name: AC
Who do you know with myeloma?: Myself
When were you/they diagnosed?: Dec 2015
Age at diagnosis: 46

Re: Can you have myeloma & normal WBC, calcium & platelets?

by Multibilly on Sun Mar 27, 2016 8:34 am

Hi Jean,

Welcome to the forum, but sorry to hear you are having to wait on lab results (we've all been there and there's not much one can do but wait).

There are several forms of monoclonal gammopathy, including MGUS, smoldering multiple myeloma, and symptomatic multiple myeloma. And each one of these gammopathies can present in different ways with differing lab results.

What symptoms led your doctor to think you might have a monoclonal gammopathy?

While multiple myeloma can certainly cause one's WBC, platelet, and calcium levels to be out of range, one can also present with all of these values being in a normal range (as is my case with smoldering multiple myeloma). An immunofixation electrophoresis and quantified immuno­globulin test are good follow-up tests to get given your current lab results. How are your hemoglobin and creatinine levels doing?

Best of luck with this and let us know how things turn out.

Multibilly
Name: Multibilly
Who do you know with myeloma?: Me
When were you/they diagnosed?: Smoldering, Nov, 2012

Re: Can you have myeloma & normal WBC, calcium & platelets?

by JeanW on Sun Mar 27, 2016 4:14 pm

Thank you both for responding.

This all began with an upper respiratory infection in January. Blood work revealed high liver enzymes and elevated ALT and AST. I had however had right flank pain for some time with microscopic blood in urine. Because of the elevated liver enzymes and the flank pain, the doctor did an ultrasound and CT with contrast of abdomen and pelvic area. Liver came back with possible fatty liver and CT showed good kidney function with some small cysts on right kidney.

Doctor ordered specific protein analysis showing the high levels of alpha with faint atypical staining in the gamma region (1.4%, 0.11 g/dl); Such staining may be reactive, idiopathic or neoplastic (related to myeloma, MGUS, or lymphoma)

The urine electrophoresis shows pattern of mixed tubular and glomerular protenuria commonly seen with chronic renal failure, but may also be seen with hemodynamic alterarions. No evidence of free light chains in this urine.

Creatinine levels in January present at 1.01 with normal ranges being 0.55-1.02, so on high end and hemoglobin at 15.3 woth normal being 12.0-16.0, so both on high end.

Thank you for reading such a lengthy post and for your kind responses. Any and all help is so very much appreciated.

JeanW


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