[Marti]

Myeloma Genetics

by Marti on Mon Nov 28, 2011 11:34 am

Just released story from England refers to the FIRST identified possible genetic contribution to myeloma - my wife died last year from myeloma/amyloidosis and some of my research has indicated other possible genetic factors although I don't pretend to understand much of the scientific data... Below is a table from http://www.nature.com/bmt/journal/v38/n1/full/1705395a.html




Multiple myeloma-associated AL amyloidosis: is a distinctive therapeutic approach warranted?
N J Bahlis and H M Lazarus

BACK TO ARTICLETable 1. Relevant genes with significantly higher () or lower () expression in AL plasma cells (ALPC) compared to myeloma plasma cells (MMPC)
Next table | Figure and tables index
Gene symbol Name of gene Expression in ALPC vs MMPC Gene function
RB1/Rb Retinoblastoma Role in cell cycle regulation and apoptosis
CCND1 Cyclin D1 Required for cell cycle G1/S transition
NFB1A Inhibitor of nuclear factor of light chain gene enhancer in B cells Regulates NFB, ICAM1, RELA, RELB
CXCL12 SDF1 Chemokine, cell migration and invasion
MYC v-myc myelocytomatosis viral oncogene homolog Role in cell cycle progression, apoptosis and cellular transformation
p53 Tumor protein p53 Regulation of cell cycle, specifically in the transition from G0 to G1
E2A E2A immunoglobulin enhancer binding factors E12/E47 Regulates B-cell development
XRCC5 Ku80 Repair of DNA double-strand break
IL6ST IL6 signal transducer Signal transducer shared by many cytokines, including interleukin 6 (IL6)
CASP3 Caspase 3 Role in the execution-phase of cell apoptosis
CDK4 Cyclin-dependent kinase 4 Important for cell cycle G1 phase progression; responsible for the phosphorylation of retinoblastoma gene product (Rb).

(Modified from Abraham et al. 19).

[Dr. Peter Voorhees]

Re: Myeloma Genetics

by Dr. Peter Voorhees on Mon Dec 05, 2011 4:32 am

Dear all,

The study to which Marti refers is described in the following Myeloma Beacon article:

https://myelomabeacon.org/news/2011/11/28/genetic-difference-linked-to-increased-risk-of-multiple-myeloma/

This is an important study that provides insight into genetic risk factors for this disease. However, it is important to point out that there are likely to be many risk factors for myeloma, both environmental and genetic, and the genetic changes that the investigators identified only account for some of the cases. Additionally, risk factors in patients of European background may be different than risk factors in people of different ethnic and racial background. It is likely that on-going research will identify additional factors that predict risk.

Pete V.