[penbed]

MGUS with heterozygous Factor V Leiden mutation

by penbed on Mon Mar 12, 2018 10:05 am

Hello All;

I was diagnosed last August with MGUS and was recently diagnosed with heterozygous Factor V Leiden mutation.

I am trying to find out how having this Factor V mutation may influence my MGUS, or vice versa.

Any information or perspectives would be appreciated. I cannot find much research on MGUS together with the Factor V Leiden mutation.

Thanks!

[Cheryl G]

Re: MGUS with heterozygous Factor V Leiden mutation

by Cheryl G on Thu Mar 15, 2018 8:33 am

Hello penbed,

I'm not a physician, so take this feedback with a (huge) grain of salt. However, my guess would be that the Factor V Leiden mutation that you have mainly will be relevant if your MGUS ever progresses to multiple myeloma.

Were your MGUS to progress to myeloma, some of the anti-myeloma treatments you would receive increase the chance of blood clots occurring in the legs and lungs, which can be very dangerous, since the blots can break loose and cause strokes. Due to the increased risk of clots, myeloma patients routinely take aspirin or other drugs to lower the risk of blood clots.

Since the Factor V Leiden mutation also increases the chances of such clots, in your case, if your MGUS progressed to myeloma, your doctors probably would recommend treatment with drug regimens that are particularly good at preventing blood clots. Instead of just aspirin, for example, they might recommend that you do daily self injections of a low molecular weight heparin, such as Lovenox (enoxaparin), or one of the new oral anti-coagulants, such as Xarelto (rivaroxaban) or Eliquis (apixaban).

I wasn't able to find any evidence that having the Factor V Leiden mutation affects your risk of pro­gressing from MGUS to myeloma. As you know, the risk generally is not very high, on the order of 1-3 percent per year for an "average" MGUS patient.

Good luck!

[penbed]

Re: MGUS with heterozygous Factor V Leiden mutation

by penbed on Thu Mar 15, 2018 5:59 pm

Cheryl G, thanks for the info.