[nsalcedo]

PET: "mixed density predominantly groundglass lesion"

by nsalcedo on Wed Dec 05, 2018 12:26 pm

Hi,

I week ago my doctor says for the moment I have MGUS. He order a PET scan. The results of the PET scan were:

Musculoskeletal: Centered in the marrow of the distal left femoral diaphysis, there is a mixed density, predominantly groundglass 2.0 x 1.3 cm lesion with metabolic activity to an SUV maximum of 2.3.

No other metabolically active osseous lesions are identified. Subtle lucent subcentimeter lesions adjacent to the SI joint are nonspecific and metabolically inactive.

Would this result indicate a lesion that would change my diagnosis to multiple myeloma?

(My hemoglobin is 13.8, and the doctor put me on IV iron. My bone marrow shows 5-10 percent plasma cells. M-spike of 2.4 g/dL, or 24 g/l .)

[Ron Harvot]

Re: PET: "mixed density predominantly groundglass lesion"

by Ron Harvot on Sun Dec 08, 2019 9:43 am

The quick answer is no. A single lesion is not an issue and given only 5-10% bone marrow involvement falls well below the standard criteria. I have to assume that your serum free light chain results were not significant and that the SPEP did not result in a mentionable M Spike. So just keep monitoring. An MGUS diagnosis does not mean you will progress to full multiple myeloma.