hi, i'm not sure I am even posting in the right place, but I am looking for feedback on what I believe is MGUS...or maybe not?
long story short, i have severe anemia and that's what led me to a hematologist who ordered testing.
immunoelectropheresis protein total 7.6
albumin 4.0
a/g ratio 1.1
alpha 1 globulin .01
alpha 2 globulin 0.7
beta 1.7
gamma 0.9
igg 1055
iga 855
igm133
mspike 0.1
sed rate 25
immunofixatio interpretation : 2 IGA lambda bands seen
immuno/protein electrophoresis ur
protein electrophoresis, urine protein, total 12
remarks: unable to detect a electrophoretic pattern
i just had a bone marrow biopsy done a few days ago and awaiting those results...
the dr is almost 100% certain i have MGUS, ruling out SMM....
i'd appreciate anything anyone would like to contribute, desperate!
PS: apparently i posted this twice and i apologize... please respond to the evndnl94 post..thanks!
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Re: MGUS, smoldering myeloma, or ... ?
Just an update. Saw the dr today for my results of the bone marrow biopsy. My plasma cells were at 10%. Was officially diagnosed with smoldering myeloma! I really thought i was going in to get the MGUS diagnosis, but to my dismay I was wrong.
I just wish someone can sum this up for me. Is it MGUS, then smoldering, then multiple myeloma? Is it transitions to the disease? Please, someone help me figure this out.
Thanks in advance.
I just wish someone can sum this up for me. Is it MGUS, then smoldering, then multiple myeloma? Is it transitions to the disease? Please, someone help me figure this out.
Thanks in advance.
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evndnl94 - Name: lyn
- Who do you know with myeloma?: no one
Re: MGUS, smoldering myeloma, or ... ?
Lyn,
There seems to be a growing consensus among myeloma specialists that MGUS, smoldering myeloma, and multiple myeloma are different manifestations of basically the same disease, with MGUS on one of the spectrum, and multiple myeloma on the other.
This does not mean, however, that everyone diagnosed with MGUS eventually progresses to smoldering myeloma, or that everyone diagnosed with smoldering myeloma eventually progresses to multiple myeloma.
Most MGUS patients, in fact, never progress to smoldering myeloma, and many smoldering myeloma patients never progress to multiple myeloma.
In terms of smoldering myeloma, the current estimates are that newly diagnosed smoldering myeloma patients have a 10% average annual risk of progression to multiple myeloma in the 5 years following diagnosis, decreasing to 3% annually for the following 5 years, and then lowering to a 1% annual rate of progression.
One thing that you and your physician should do now is have your bone marrow biopsy analyzed -- if it hasn't already been analyzed -- to determine what chromosomal abnormalities the plasma cells in the marrow have (if they have any).
The presence of certain chromosomal abnormalities can indicate a higher risk of the smoldering myeloma progressing to multiple myeloma. This is discussed in an article the Beacon published earlier this year,
https://myelomabeacon.org/news/2013/03/29/chromosomal-abnormalities-smoldering-myeloma-high-risk-progression/
There are LOTS of useful discussions about smoldering myeloma in this forum. Just do a search on the keyword "smoldering" (without the quotation marks) in the forum search box at the top of the forum.
You also probably should consider taking some time to review the Beacon's news and opinion articles about smoldering myeloma, which are listed here:
https://myelomabeacon.org/tag/smoldering-multiple-myeloma/
Good luck!
There seems to be a growing consensus among myeloma specialists that MGUS, smoldering myeloma, and multiple myeloma are different manifestations of basically the same disease, with MGUS on one of the spectrum, and multiple myeloma on the other.
This does not mean, however, that everyone diagnosed with MGUS eventually progresses to smoldering myeloma, or that everyone diagnosed with smoldering myeloma eventually progresses to multiple myeloma.
Most MGUS patients, in fact, never progress to smoldering myeloma, and many smoldering myeloma patients never progress to multiple myeloma.
In terms of smoldering myeloma, the current estimates are that newly diagnosed smoldering myeloma patients have a 10% average annual risk of progression to multiple myeloma in the 5 years following diagnosis, decreasing to 3% annually for the following 5 years, and then lowering to a 1% annual rate of progression.
One thing that you and your physician should do now is have your bone marrow biopsy analyzed -- if it hasn't already been analyzed -- to determine what chromosomal abnormalities the plasma cells in the marrow have (if they have any).
The presence of certain chromosomal abnormalities can indicate a higher risk of the smoldering myeloma progressing to multiple myeloma. This is discussed in an article the Beacon published earlier this year,
https://myelomabeacon.org/news/2013/03/29/chromosomal-abnormalities-smoldering-myeloma-high-risk-progression/
There are LOTS of useful discussions about smoldering myeloma in this forum. Just do a search on the keyword "smoldering" (without the quotation marks) in the forum search box at the top of the forum.
You also probably should consider taking some time to review the Beacon's news and opinion articles about smoldering myeloma, which are listed here:
https://myelomabeacon.org/tag/smoldering-multiple-myeloma/
Good luck!
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