[lonely artist]

MGUS, myeloma, and oligoclonal bands in spinal fluid

by lonely artist on Sun Sep 02, 2018 5:21 pm

I was diagnosed about 18 months ago with IgG lambda MGUS. In addition to my numbers slowly and steadily climbing with each new testing, I am also in the final stages of being diagnosed with multiple sclerosis. The MGUS has made this a bit more difficult, in part because I don’t want to do anything to wake the sleeping giant (multiple myeloma). As it’s another month before my next neurology appointment and six weeks to my next oncology appointment I figured I would ask one question here while waiting.

Lumbar puncture is one puzzle piece used to diagnose multiple sclerosis, but it also is used when diagnosing multiple myeloma, as abnormal IgG bands can be seen in spinal fluid. If my neurologist wants to do a lumbar puncture on me, will it show abnormal bands because of the MGUS? If this is the case. I would consider it not worth the risk.

I’ve tried to find some information on this myself, but the available literature seems to only address this when active myeloma is involved and not MGUS.

Many thanks in advance!
Victoria

[christophe]

Re: MGUS, myeloma, and oligoclonal bands in spinal fluid

by christophe on Tue Sep 25, 2018 9:54 am

Hello,

I find your question interesting because my spinal tap showed one oligoclonal band and I've always wondered if that was related to my IgA MGUS. Experts I talked to do not seem to think there is a link, but I don't know the reason for the oligoclonal band.