[KimK]

MGUS, multiple myeloma, and hyperparathyroidism

by KimK on Mon Sep 28, 2015 8:41 pm

Good evening all,

I have done much reading here about a "relationship" between multiple myeloma (or MGUS or smoldering multiple myeloma) patients and hyperthyroidism, but does anyone know if there is a relationship with hyperparathyroidism?

Wednesday is our BIG visit with the hematologist, and there is much data and testing that the family GP has provided for him. But we still have not heard from the endocrinologist that my hubby was referred to for his elevated PTH. Family GP said to mention it to the hematologist, to see if he would talk with an endocrinologist in that hospital, to see if there was a relationship (other than the moderate osteoporosis).

Thanks all!
Kim

[Aussie Annie]

Re: MGUS, multiple myeloma, and hyperparathyroidism

by Aussie Annie on Mon Oct 23, 2017 5:24 pm

Hi Kim,

I hope your husband is doing well.

I have a slowly progressing MGUS and recently was diagnosed with hyperparathyroidism. I am wondering if you were able to get any further information regarding a connection between the two.

Best wishes,
Ann-Marie

[Eileenk]

Re: MGUS, multiple myeloma, and hyperparathyroidism

by Eileenk on Tue Oct 24, 2017 8:05 am

Hi Kim,

I have been diagnosed with smoldering multiple myeloma just last month, with IgA and 30-40% bone marrow. Just prior to this diagnosis (in early July), I had surgery for primary hyper­para­thryoidism due to elevated PTH and elevated calcium. In addition, my latest DEXA shows that I have osteoporosis (previously over the last 4 years, I had been diagnosed as having osteo­penia, so the jump to osteoporosis was disturbing, as I'm 49 years old). I do also have Crohn's disease, so absorption of nutrients is not always perfect.

My myeloma specialist has been wondering whether my elevated calcium was due to the hyper­para­thyroidism or a defining myeloma event (the C in crab). We are watching my calcium levels to see how they respond over the next few months. I will say, they did remove 1 parathyroid adenoma, however it was not significantly large, yet my PTH did drop significantly in the operat­ing room, so I hope that was the culprit.

I have had a Zometa treatment due to my bone situation as an aid to prevent fractures.

I am the one that asked for the PTH to be measured, I now wonder, if I hadn't, would they have just assumed active myeloma and started treatment (elevated calcium and osteoporosis). I also wonder which is correct.

Sorry I don't have answers as to whether there is a "connection," as I am trying to figure this out myself. If you discover anything, please keep us updated, and best of luck to your husband.

Eileen