[Jeff]

MGUS with missing chromosome 13

by Jeff on Fri Oct 05, 2012 8:29 am

I was diagnosed with MGUS in March of 2012. Before I was diagnosed, one of doctors said I had iron deficiency and my iron was a 6.

So I went to blood doctor and after running several test he said I had B-12 deficiency and pernicious anemia. Said he wanted to do a bone marrow biopsy. He said that I had 8% myeloma cells and had MGUS. He also said that I was missing chromosome 13.

My wife and I were reading something somewhere and it said that all patients that has MGUS and that are missing chromosome 13 would most likely develop multiple myeloma.

I wasn't sure how accurate this was.

Thank you
Jeff

[Billy1]

Re: MGUS with missing chromosome 13

by Billy1 on Fri Oct 05, 2012 11:22 am

To be diagnosed with MGUS you must of had other tests conducted to determine the type and level of the Monoclonal Protein present. The tests I refer to are Serum SPEP, or 24/hr UPEP, IGG Quantification, and possibly the FLC (Freelite) serum test along with the normal CBC and CMP. These tests would tell you the following for determination of MGUS.
1) M-Spike (must be below 3 gdL for MGUS)
2) Type of monoclonal protein (Determined by immunofixation, SPEP or UPEP)
3) No. and Type of Free Light Chains if any. (Freelite Test)
4) Your Hgb level (Anemia) from CBC
5) Your Creatinine level (Kidneys) from CMP
6) Your Calcium level from CMP

The definition for someone with MGUS is a M-Spike below 3 gdL and less than 10% bone marrow plasma cells and no "CRAB" symptoms. "C" is for normal calcium levels, "R" is for normal renal function, "A" is for Anemia with a HgB level of not less than 2 below the Min. normal level, and "B" is no bone lesions or other.

You state that they found deletion of chromosome 13 on your BMB but you did not say if that was discovered by Cytogenics or by iFISH, It makes a difference for possible progression.

I would ask your Dr. what your M-Spike was and the type of paraprotein found, ie: IGG, IGA, or IGM. and if it was Kappa, or Lambda type.

I would recommend a second opinion with a Hematologist with extensive multiple myeloma experiance.

Regards:

Billy1