[IdenticalTwin]

MGUS blood tests and rabies immune globulin / vaccine

by IdenticalTwin on Sat Nov 21, 2015 5:30 pm

Could my recent massive injection of post exposure rabies immune globulin and four injections of the rabies vaccine interfere with results of subsequent annual blood test to monitor MGUS?

I see that the rabies globulin binds to IgG. I'm thinking I should wait several months or a year for the vaccine / immune globulin proteins to clear out before I have my MGUS blood work.

[Multibilly]

Re: MGUS blood tests and rabies immune globulin / vaccine

by Multibilly on Sat Nov 21, 2015 7:48 pm

With MGUS, one is primarily monitoring the monoclonal component of one's involved immunoglobulin (M-spike) and other key markers such as one's free light chain values, calcium, hemoglobin, creatinine, etc.

Assuming you have IgG-type MGUS, you can always write off any increase in the total IgG level (normal polyclonal IgG + IgG M-spike) to the rabies vaccine, assuming it does indeed increase the polyclonal IgG level. But I wouldn't think that the rabies vaccine would impact one's M-spike level.

But I'm not a doc by any stretch of the imagination, so please confirm with yours.