[IURox]

Meaning of bone marrow biopsy results?

by IURox on Tue Mar 01, 2016 4:01 pm

Can someone help explain these biopsy results? Any help would be greatly appreciated!

Results:

Elevated white blood cell count, unspecified, thrombocytopenia, unspecified.

Interpretation: Increased CD 34(+) myeloblasts [~9.0%]. Increased CD117(+)/CD34(-) immature granulocyte population [~15.0%].

Comments: The patient's leukocytosis, monocytosis, thrombocytopenia and anemia are noted. The findings are consistent with a high grade myeloid neoplasm. While the CD117 population may represent CD34(-) blasts, raising the blast percentage to over 20%, this population may include immature granulocytes (e.g. pro­myelocytes). Definitive distinction, and final interpretation of the above results, requires correlation with the morphologic findings.

Cell Population % Total Population Analysis

Lymphocytes 3.9% 7.1% B cells [CD19(+), CD20(+) with a Kappa/Lambda ratio = 1.4:1]72.1% T cells: [CD3(+), CD4/CD8 ratio = 1.80:1, CD5(+) and CD7(+)] 13.6% NK cells: [CD3(-), CD7(+), CD11b(+), CD56(variable+)]

Monocytes 3.4% [CD11b(+), CD14(+), CD33(+), CD64(+)]

Granulocytes 65.2% Neutrophils: [CD10(+),CD11b(+), CD13(+), CD15(+), CD16(variable+), D33(+)]

CD45 Dim 25.3% See abnormal cells.

CD45 Neg 2.1% Erythroid cells, CD45[-] cells, & debris comprise the majority of the remaining events.

Plasma Cells 0.09%[CD138(+), CD38(+),c-kappa:c-lambda ratio = 1.9:1]

Abnormal Cells 9.0%

Myeloblasts:Positive markers: CD45 (dim), CD34, CD117, HLA-DR, CD13, CD33, CD11b (partial), c-MPO
Negative markers: CD3 , c-CD3 , CD4, CD5, CD7, CD8, CD10, CD19, CD20, c-CD79a,
CD14, CD15, CD16, CD56, CD64, CD71 and c-TdT.
(Specimen Viability: 100%)

Immunophenotyping: CD3, CD4, CD5, CD7, CD8, CD10, CD11b, CD13, CD14, CD15, CD16, CD19, CD20, CD33, CD34, CD38, CD45, CD56, CD64, CD117, CD138, HLA-DR, kappa, lambda, c-kappa, c-lambda, c-MPO, c-TdT, c-CD79a, c-CD3

Microscopic Description: Bone marrow smear and cytospin: mixed hematopoietic elements; increased blast population appreciated. (Cell yield: 202.02 Million )

Flow Cytometry

[Cheryl G]

Re: Meaning of bone marrow biopsy results?

by Cheryl G on Tue Mar 01, 2016 4:35 pm

Welcome to the forum, IURox.

To help us put your bone marrow biopsy results in per­spective, can you give us some back­ground on why the biopsy was done? Have you been diagnosed or treated for multiple myeloma or any other plasma cell disorder?

[IURox]

Re: Meaning of bone marrow biopsy results?

by IURox on Wed Mar 02, 2016 9:35 am

Well, my doctor called yesterday. I did not think I would here from him so fast. But it is acute myeloid leukemia (AML). Blah. A shock to say the least. I see him Thursday, so I guess all my questions will be answered then.

Hopefully!

[Cheryl G]

Re: Meaning of bone marrow biopsy results?

by Cheryl G on Sat Mar 12, 2016 1:13 pm

Sorry to hear about your diagnosis, IURox. I hope your doctors are able to come up with a good way to treat the AML.

[pinball]

Re: Meaning of bone marrow biopsy results?

by pinball on Fri Apr 08, 2016 1:04 am

I guess you may never read this given your new diagnosis, but just in case:

Sorry to hear of the diagnosis, my wife in early 2013 was diagnosed with chronic myeloid leu­kemia, which was in the second phase (the third phase, blast, is similar to AML). Thankfully she responded to a late gen TKi agent and returned to the chronic phase and while her life long treatment is rough due to side effects, I can only imagine how rough AML treatment could be, but hopefully it's at an early stage and you can conquer it quickly). Best wishes.

I recall the day we were given her diagnosis, since then we've switched oncologists for her twice, hopefully you have a great specialist which seems to make all the difference. It took much time for us to understand the disease and treatment process, which may include a allogeneic stem cell transplant if her treatment should ever began to fail.

It's crazy how often I hear of leukemia cases in the past 3 years, especially younger patients in their 30s and 40s, Advancements in treatment are wonderful, but it's alarming that so many new cases are appearing.

I always think of the Indianapolis NFL coach who was diagnosed with AML and was back to work the following year, indicating amazing treatment options. Best wishes to get better.