Does anyone know anything about cannabidiol (CBD), a non-psychoactive ingredient in marijuana that can be used in conjunction with Velcade (bortezomib) to slow down the development of tumors in multiple myeloma? It apparently has recently been shown to have clinical potential, but I'm thinking it may be illegal in America.
With my life at stake who cares about illegal. Do you know of anyone doing funded trials on human subjects, anyone prescribing this remedy.
"The effects of cannabidiol and its synergism with bortezomib in multiple myeloma cell lines. A role for transient receptor potential vanilloid type-2", Morelli et al, Int J Cancer. 2014 Jun 1;134(11):2534-46. Epub 2013 Dec 2.
Abstract: Multiple myeloma (multiple myeloma) is a plasma cell (PC) malignancy characterised by the accumulation of a monoclonal PC population in the bone marrow (BM). Cannabidiol (CBD) is a non-psychoactive cannabinoid with antitumoural activities, and the transient receptor potential vanilloid type-2 (TRPV2) channel has been reported as a potential CBD receptor. TRPV2 activation by CBD decreases proliferation and increases susceptibility to drug-induced cell death in human cancer cells. However, no functional role has been ascribed to CBD and TRPV2 in multiple myeloma. In this study, we identified the presence of heterogeneous CD138+TRPV2+ and CD138+TRPV2- PC populations in multiple myeloma patients, whereas only the CD138+ TRPV2- population was present in RPMI8226 and U266 multiple myeloma cell lines. Because bortezomib (BORT) is commonly used in multiple myeloma treatment, we investigated the effects of CBD and BORT in CD138+TRPV2- multiple myeloma cells and in multiple myeloma cell lines transfected with TRPV2 (CD138+TRPV2+). These results showed that CBD by itself or in synergy with BORT strongly inhibited growth, arrested cell cycle progression and induced multiple myeloma cells death by regulating the ERK, AKT and NF-κB pathways with major effects in TRPV2+ cells. These data provide a rationale for using CBD to increase the activity of proteasome inhibitors in multiple myeloma.
Forums
6 posts
• Page 1 of 1
-
macperry - Name: Mac Perry
- Who do you know with myeloma?: me
- When were you/they diagnosed?: May 2012
- Age at diagnosis: 71
Re: Marijuana oil and Velcade
Welcome to the forum, Mac.
The journal article you mention and a wide range of related subjects are discussed in this long thread here at the Beacon's forum: Medical Cannabis Treatments? .
The article itself is not discussed until about page 4 of the thread, but other information before and afterwards is likely to answer some of your question.
We just did a search at clinicaltrials.gov to see if there are any clinical trials underway testing either "marijuana", "cannabis", or "cannabidiol" as a treatment for myeloma. We were not able to find any.
The journal article you mention and a wide range of related subjects are discussed in this long thread here at the Beacon's forum: Medical Cannabis Treatments? .
The article itself is not discussed until about page 4 of the thread, but other information before and afterwards is likely to answer some of your question.
We just did a search at clinicaltrials.gov to see if there are any clinical trials underway testing either "marijuana", "cannabis", or "cannabidiol" as a treatment for myeloma. We were not able to find any.
Re: Marijuana oil and Velcade
Macperry,
I have nothing against the medical use of marijuana or substances derived from marijuana for medical use, especially if they have been shown to have some effectiveness in a trial setting. I used federally legally prescribed Drobinal myself, which is synthetic THC, when I was having severe weight loss and no appetite when going through induction therapy with Velcade.
I had no idea that THC could be legally obtain under FDA approval for medical treatment. From listening to all the rhetoric from medical marijuana advocates here in California, I had thought that all THC was completely illegal and the only way to get if for medical use was through illegal sources and to have to smoke or eat it as marijuana.
Legal use was a big deal for me because I have a federal job that requires a security clearance and I do get drug tested. As long as I had a FDA approved prescription, which I did from my HMO doctor, I was good to go. Drobinal did not seem to help me much so I stopped using it after a few months. Though it was THC, I never felt any effect of getting high or stoned. My GF did say I seemed to be a bit more relaxed though.
I do not know if you can get cannabidiol legally as an FDA-approved substance. If it did show promise for medical use, I do not think the FDA would object to it as they have approved THC for medical use and THC is an active ingredient in marijuana that makes one high, but not the only one.
If cannabidiol is not FDA approved, you may find it hard to find a hematologist/oncologist that is willing to include it in a treatment plan, much less prescribe an illegal substance. You may be on your own.
I have nothing against the medical use of marijuana or substances derived from marijuana for medical use, especially if they have been shown to have some effectiveness in a trial setting. I used federally legally prescribed Drobinal myself, which is synthetic THC, when I was having severe weight loss and no appetite when going through induction therapy with Velcade.
I had no idea that THC could be legally obtain under FDA approval for medical treatment. From listening to all the rhetoric from medical marijuana advocates here in California, I had thought that all THC was completely illegal and the only way to get if for medical use was through illegal sources and to have to smoke or eat it as marijuana.
Legal use was a big deal for me because I have a federal job that requires a security clearance and I do get drug tested. As long as I had a FDA approved prescription, which I did from my HMO doctor, I was good to go. Drobinal did not seem to help me much so I stopped using it after a few months. Though it was THC, I never felt any effect of getting high or stoned. My GF did say I seemed to be a bit more relaxed though.
I do not know if you can get cannabidiol legally as an FDA-approved substance. If it did show promise for medical use, I do not think the FDA would object to it as they have approved THC for medical use and THC is an active ingredient in marijuana that makes one high, but not the only one.
If cannabidiol is not FDA approved, you may find it hard to find a hematologist/oncologist that is willing to include it in a treatment plan, much less prescribe an illegal substance. You may be on your own.
-
Eric Hofacket - Name: Eric H
- When were you/they diagnosed?: 01 April 2011
- Age at diagnosis: 44
Re: Marijuana oil and Velcade
Mac,
You questioned the legality of accessing CBD in America. As you read the long thread that the Beacon staff pointed to you below, I believe you can in fact acquire CBD oil in Colorado and some other states like Washington, whether it be for the medical treatment of cancer or for recreational use.
Or, as pointed out in the aforementioned thread by another poster, you can make your own oil...but many of the recipes you will find (Rick Simpson's oil, Phoenix Tears, etc) involve the use of large quantities of extremely flammable and toxic solvents which can potentially leave very toxic residues in the oil. You also have to wonder if these same solvents and their residues are carcinogenic themselves and would further exacerbate multiple myeloma, no matter how careful you are during the manufacturing process....so please proceed with caution if you go the home-made route.
Charlotte's Web is talked about on the CNN "Weed" video I posted on the aforementioned link. Note that it is produced without the use of solvents. You can find more discussion of Charlotte's Web here:
http://en.wikipedia.org/wiki/Charlotte%27s_Web_%28cannabis%29
As you will see in the above Wikipedia link, people are moving to Colorado simply to get access to Charlotte's Web for treating their medical conditions.
You questioned the legality of accessing CBD in America. As you read the long thread that the Beacon staff pointed to you below, I believe you can in fact acquire CBD oil in Colorado and some other states like Washington, whether it be for the medical treatment of cancer or for recreational use.
Or, as pointed out in the aforementioned thread by another poster, you can make your own oil...but many of the recipes you will find (Rick Simpson's oil, Phoenix Tears, etc) involve the use of large quantities of extremely flammable and toxic solvents which can potentially leave very toxic residues in the oil. You also have to wonder if these same solvents and their residues are carcinogenic themselves and would further exacerbate multiple myeloma, no matter how careful you are during the manufacturing process....so please proceed with caution if you go the home-made route.
Charlotte's Web is talked about on the CNN "Weed" video I posted on the aforementioned link. Note that it is produced without the use of solvents. You can find more discussion of Charlotte's Web here:
http://en.wikipedia.org/wiki/Charlotte%27s_Web_%28cannabis%29
As you will see in the above Wikipedia link, people are moving to Colorado simply to get access to Charlotte's Web for treating their medical conditions.
-
Multibilly - Name: Multibilly
- Who do you know with myeloma?: Me
- When were you/they diagnosed?: Smoldering, Nov, 2012
6 posts
• Page 1 of 1
Return to Treatments & Side Effects