[vanL]

Male 60-year-old with CLL & high-risk multiple myeloma

by vanL on Tue Oct 23, 2018 7:45 am

Hello all,

I am finally getting round to an introduction, though I have already posted in this thread:

"Kappa / lambda ratio & myeloma defining events" (started Aug 11, 2015)

I was diagnosed with CLL (chronic lympho­cytic leukemia) in 2014, had normal FISH, no issues, 20% marrow infiltration. Then in January 2018 they also found another clonal population of lymphocytes, with a different flow cytometry signature than the CLL, but a small (less than 5%) population in the marrow.

Over a year ago, after my second marrow biopsy, it was discovered there was a 50% marrow population of clonal plasma cells. Due to the way they looked under the microscope, it was assumed they were lympho­plasma­cytic cells (similar to Waldenstrom's macro­globu­linemia).

But in June 2018 a CBC found my eGFR dropped from 87 to under 50 and my creatinine increased by 50% or so to around 1.57 mg/dl. So, another marrow biopsy and flow cytometry testing on the plasma cells revealed t(14;16), gain 1q, del(13q), 50% marrow infiltration. This trumps the CLL and now the combined marrow impact is around 70% or higher.

I will be meeting later this month with a myeloma specialist to discuss treatment. My cyto­genetics, particularly t(14;16) and gain 1q, are a high risk combination per the updated Mayo Clinic "mSmart" guidelines, and my doctor already has discussed the possibility of a tandem transplant in a discussion we had a month ago, but we'll see what her thoughts are when I meet with her this month.

Thanks to all for being here.

[C00kie]

Re: Male 60-year-old with CLL & high-risk multiple myeloma

by C00kie on Wed Dec 26, 2018 4:49 am

Hi there,

After reading your post, it amazes me how much you must be going through and you’re taking it in stride dealing with everything. I hope you know from your last appointment now what the next steps are for you.

All the best Van, and hope your next line of treatment is successful.

Suzanne.