[pattyk66]

M-spike has disappeared

by pattyk66 on Mon Sep 28, 2015 11:13 pm

My recent serum electrophoresis test came back normal. I was diagnosed with MGUS in 1995. I went to the Mayo Clinic for a second opinion, and they confirmed the diagnosis. My values held steady, and in 2010 my hematologist told me my numbers were less than they were when first diagnosed.

I had my annual electrophoresis test done in June 2015. My PCP left her practice around the same time and this test result fell into the cracks. While gathering lab results for my initial visit with new PCP, I came across the lab report stating IgG is normal.

My question is: Does this mean I no longer have MGUS? Or is it possible the test was done wrong?

[Multibilly]

Re: M-spike has disappeared

by Multibilly on Tue Sep 29, 2015 8:38 am

Hi Patty,

I want to make sure I understand your post. Having a normal IgG level is a little bit different than having a serum electrophoresis test that shows no M-spike (one can have a small or modest M-spike, but still have a normal IgG level). Or are you saying that you had no M-spike on your electrophoresis test and your quantified IgG level was also normal?

Did they run a separate immunofixation test? What were those test results?

Did they also run a free light chain assay as part of your tests? Were your lambda, kappa and kappa/lambda FLC values normal?

In any case, I might suggest getting re-tested and having a serum immunofixation, serum electrophoresis, and a free light chain assay and take it from there. Lab errors do occur, so I would first try to rule out that possibility before trying to figure out what is going on.