[dolphinnose]

Drop in M-spike - does it mean anything?

by dolphinnose on Mon Dec 07, 2015 10:03 am

I have been diagnosed with MGUS about a year back. The last few tests have shown an M-band / M-spike of 1.30 g/dL (13 g/L). My latest serum protein electrophoresis (SPEP) test says it is 0.96 g/dL (9.6 g/L).

I have been getting my SPEP tests done at the same lab. Can I consider that my M-spike is getting reduced and possibly it may disappear completely?

Or the difference is not really big enough from 1.30 to 0.96 to feel happy about?

Thank you

[Dianem]

Re: Drop in M-spike - does it mean anything?

by Dianem on Mon Dec 07, 2015 1:50 pm

Hi -

I too have MGUS (IgG) and 4 years ago when diagnosed my M spike was 1.5 and now it is 0.8. I asked the same question when my M-spike started going down and was told MGUS does not go away.

Yes, you should be happy it is going down.

Like you, I go to the same lab once/year for testing. I've taken Synthyroid for low thyroid for years and, when diagnosed with MGUS, reduced the dosage and question if this is why the spike went down.

Diane

[dolphinnose]

Re: Drop in M-spike - does it mean anything?

by dolphinnose on Mon Dec 07, 2015 11:41 pm

Thank you Diane for your reply. Well, was hoping it would go down to zero
I too have thyroid and I take 25 mcg but I have not changed my dose. My MGUS and thyroid had surfaced around the same time though.
I guess I will take this drop in M-spike as blessing disguise

Thank You

[Multibilly]

Re: Drop in M-spike - does it mean anything?

by Multibilly on Tue Dec 08, 2015 8:18 am

Dolphinnose,

Your M-spike is not going to go away, but it could very well bounce around in a range for the rest of your life. With MGUS and SMM, one's M-spike will go up and down and change like the tides.

You can see how my numbers ebb and flow here:

https://myelomabeacon.org/forum/fenofibrate-tricor-and-multiple-myeloma-t2690-40.html#p35483

[dolphinnose]

Re: Drop in M-spike - does it mean anything?

by dolphinnose on Tue Dec 08, 2015 11:45 am

Thanks Multibilly. I have been following this forum for a while and you have been a great contributor. Thanks for the support and help you have been providing to people like me.

I guess for now I will be happy with the drop and will see what is in store in the future. I have been hitting the gym ever since I was diagnosed with MGUS and probably it is helping me. I am vegetarian so no red meat

Thanks again

[Tiaannabelle]

Re: Drop in M-spike - does it mean anything?

by Tiaannabelle on Tue Mar 21, 2017 9:07 am

Good morning all!

My M-spike was 1.1 g/dL at diagnosis 2 years ago. Then: 1.0, 1.4, 1.6, 1.4, 1.6, 1.4, and now, this month, 1.3! I'll take it!

But I wanted to also say I had taken levothyroxine for low thyroid for many years, at 50 mcg, but it was increased to 75 mcg 15 months ago. So, Dianem and Dolphinnose, I don't believe there's any correlation.

Blessed day and low M-spikes, all!