[Rosie+George]

Re: Lyme disease

by Rosie+George on Sun Oct 19, 2014 1:19 pm

Yes I agree regarding early detection and treatment with Lyme disease can have very good or even curative outcomes. That is why I mentioned only chronic lyme sufferers which fall into that small subset category that may be at risk for an inflammatory process.

As I mentioned there has been clinical studies linking MGUS to a possible causal link to those whom may have auto immune disease. Pubmed is a resource for the scientific community to locate scientific research articles. I personally am a clinical scientist and often use this web tool to gain access to a multitude of respected journals and the latest scientific abstracts and case studies.

Some research articles that I was referencing can be found there. For example:


http://www.ncbi.nlm.nih.gov/m/pubmed/24451437/

Prior autoimmune disease and risk of monoclonal gammopathy of undetermined significance and multiple myeloma: a systematic review.
AuthorsMcShane CM, et al. Show all Journal
Cancer Epidemiol Biomarkers Prev. 2014 Feb;23(2):332-42. doi: 10.1158/1055-9965.EPI-13-0695. Epub 2014 Jan 22.


http://www.ncbi.nlm.nih.gov/m/pubmed/18239085/?i=2&from=/24451437/related

Risk of multiple myeloma and monoclonal gammopathy of undetermined significance among white and black male United States veterans with prior autoimmune, infectious, inflammatory, and allergic disorders.
AuthorsBrown LM, et al. Show all Journal
Blood. 2008 Apr 1;111(7):3388-94. doi: 10.1182/blood-2007-10-121285. Epub 2008 Jan 31.

http://www.ncbi.nlm.nih.gov/m/pubmed/21998210/?i=3&from=/24451437/related

Personal and family history of immune-related conditions increase the risk of plasma cell disorders: a population-based study.
AuthorsLindqvist EK, et al. Show all Journal
Blood. 2011 Dec 8;118(24):6284-91. doi: 10.1182/blood-2011-04-347559. Epub 2011 Oct 13.

http://www.ncbi.nlm.nih.gov/pmc/articles/PMC1004194/?page=2

Rheumatoid arthritis, malignancy, and paraproteins.
AuthorsKelly C, et al. Show all Journal
Ann Rheum Dis. 1990 Sep;49(9):657-9.

****Ultimately there are no conclusive studies that point to the absolute or definite cause of MGUS. However, the science can speculate links. Just a few years ago any causal links were debunked, yet more recent clinical case trials reveal potential causal speculations. Whether conclusively defined or not the data now available should lead to at least surveillance (testing in lay mans terms). Ultimately in any disease origin, early detection provides the best outcome. This is the point I was trying to make.

[Toni]

Re: Lyme disease

by Toni on Sun Oct 19, 2014 3:34 pm

Oh indeed, and I truly appreciate your listing so many wonderful studies. I think even just the empirical information from those of us MGUSers on this forum supports the idea of inflammation/autoimmune being a finding among us.

Thank you for listing these studies so we can all see them easily. I just wanted to make sure I wasn't misleading anyone because I fortunately did discover the tick bite very early and I believe received sufficient treatment. But certainly, there seems to be issues with individuals who have undiagnosed Lyme's,.