[curiousG]

Loss of IGH/14q DNA sequence - FISH

by curiousG on Thu Oct 30, 2014 2:45 pm

Can anyone tell me what "Loss of IGH/14q DNA sequence" means? This was listed on FISH in addition to "Gain of chromosomes 7, 9 and 15".

I have attempted to research this but I am not really sure what I am looking for. I am not sure if 14q is the same thing as 14q.32.1 or 14q.32.2 or if a "loss" is the same thing as a "deletion".

Obviously, I am curious as to how this finding affects or could possibly affect prognosis. FISH stated it was unknown. I did ask my mom's oncologist during our last visit and he said he didn't know.

Any direction on this would greatly be appreciated - Thank you!

[Dr. Jacob Laubach]

Re: Loss of IGH/14q DNA sequence - FISH

by Dr. Jacob Laubach on Mon Nov 03, 2014 1:50 am

Hello Crystal,

“Loss” and “deletion” are considered synonymous in this context. Both refer to the loss of a specific region of the genome, in this case the q region of the 14 chromosome, a site that con­tains DNA encoding the immunoglobulin heavy chain (IGH). This abnormality is not associ­ated with “high risk.” Rather, it is associated with “standard risk” myeloma.

Best of luck to your mother. Please keep us posted on how she is doing.

[curiousG]

Re: Loss of IGH/14q DNA sequence - FISH

by curiousG on Wed Nov 05, 2014 12:21 pm

Thank you Dr. Laubach - I appreciate your response! My mother just finished her first round of CyBorD so we are eagerly awaiting her SPEP results. I am trying to reign in my expectations but am still excited and hopeful!