[debbra]

Liver problems and smoldering myeloma?

by debbra on Thu Dec 12, 2013 3:40 pm

In 3 months liver, ast and alt, 10x, ast -126, alt -190. Dont drink alcohol, no new meds. Negative for hepatitis, have 15% plasma in bone marrow. Doctor says possibly from fatty liver.

Could myeloma be causing this sudden increase? Very concerned.

[debbra]

Re: Liver problems and smoldering myeloma?

by debbra on Thu Dec 12, 2013 10:15 pm

Sorry, did not make it clear. I do have monoclonal, I am seeing an oncologist, I do have m-protein in my blood.

I was diagnosed last year, the liver alt and ast levels was something that just happened in the last few weeks. I am seeing 2 doctors, they ran dozens of blood tests. No hepatitis. Don't drink. They really cant figure what is going on.

Levels of alt and ast, increased 10 times in about 4 months. Just trying to find out if this kind of liver problems could be related to smoldering myeloma.

Thanks for your response. I guess I am trying to see if anyone else ever experienced sudden liver problems with myeloma.

[Dr. Adam Cohen]

Re: Liver problems and smoldering myeloma?

by Dr. Adam Cohen on Fri Dec 20, 2013 12:08 am

Myeloma only very rarely involves the liver, and when it does, there are usually masses or other abnormalities visible on imaging tests like ultrasounds or CT scans. So it's pretty unlikely to be from myeloma. Sometimes other viruses besides hepatitis viruses can cause elevated liver enzymes, such as EBV (cause of mononucleosis).

There are also autoimmune diseases that can cause these findings, though I suspect your doctors checked for this in the blood work you had. You can always get a liver biopsy to find out the cause, though your levels are still relatively low and it may be worth just observing for a while with serial labs to see what the trend is before committing to this invasive measure. Hope this is helpful.