[Eddie]

Liver function during RVD induction therapy

by Eddie on Fri May 15, 2015 1:43 pm

Hi,

I have started my RVD [Revlimid, Velcade, dexamethasone] induction 3 weeks ago and have noticed significant degradation in liver function blood test results.

In addition to RVD, I take Biaxin [clarithromycin] 500mg / day and acyclovir 400mg/day.

My doctor's office did not raise this an alert yet, but I am worried.

I have decided to start induction due to just one lesion in the skull. Otherwise, I have been asymptomatic.

How worried should I be that I may permanently damage my liver, or are these elevated liver function blood test results expected during RVD treatment?

Component Range 4-month Cycle 1 Cycle 1
average Day 1 Day 15
prior to 1st 3rd
RVD Vel/Dex Vel/Dex

Albumin 3.5-4.9 G/DL 4.1 4.2 3.8
ALK.Phosphatase 30-110 U/L 135 142 221
ALT(SGPT) 1-53 U/L 32 41 276
AST(SGOT) 1-50 U/L 43 72 358
Bilibrubin,Total 0.1-1.2 mg/dL 0.8 0.9 1.3
LD(LDH) 100-220 U/L 184 193 480

[goldmine848]

Re: Liver function during RVD induction therapy

by goldmine848 on Fri May 15, 2015 7:37 pm

I have had elevated LDH, AST and ALT for much of the time since my diagnosis 2 years ago. About 10 months ago, I had a consultation with a liver doctor, and he told me not to worry, at least for now. My AST and ALT have been lower than yours. I would request a referral to an expert.

[cdnirene]

Re: Liver function during RVD induction therapy

by cdnirene on Sat May 16, 2015 2:42 am

You might find this thread of interest:

"Revlimid and high ALT - liver damage" (started March 23, 2012)