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Switching to light-chain multiple myeloma at relapse

by blair77 on Thu Mar 19, 2015 3:37 pm

Does myeloma that once secreted an M protein relapse as "light chain" only often?

blair77
Who do you know with myeloma?: My husband
When were you/they diagnosed?: April 2013
Age at diagnosis: 43
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Re: Switching to light-chain multiple myeloma at relapse

by Ron Harvot on Fri Mar 20, 2015 12:20 pm

It does happen occasionally. Pat Killingsworth, who writes a regular column for the Beacon, went from having an M spike to having nonsecretory multiple myeloma. The disease can produce multiple clones. The initial multiple myeloma treatment may suppress the once dominant clone, but not impact others that later become dominant.

Ron Harvot
Name: Ron Harvot
Who do you know with myeloma?: Myself
When were you/they diagnosed?: Feb 2009
Age at diagnosis: 56
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