[natboris2001]

Lambda free light chain level increasing

by natboris2001 on Tue Jan 26, 2016 2:15 pm

My 66-year-old hubby had an auto stem cell transplant on December 21. His labs from a couple of weeks ago show kappa free light chain (FLC) at 13.94 (normal range 3.3-19.4) , and the kappa/lambda ratio is 1.21 (normal range 0.26-1.65). His lambda FLC, while still within the normal range, has crept up a bit to 11.53. When we left the hospital, it was 8.96. Normal shows a range of 5.71-26.3.

What does this mean?

[Ellen Harris]

Re: Lambda free light chain level increasing

by Ellen Harris on Tue Jan 26, 2016 4:43 pm

It is normal for the kappa and lambda to move around a bit. They are both well within normal limits. Certainly check with your doctor, but I don't think you have anything to worry about!

Any M-spike?

Good luck with his continued recovery from the autologous stem cell transplant. The 100 day check up is when the effectiveness of the transplant is evaluated. Before then, it is premature to assume anything, either positive or negative.

Please let us know how your husband is doing with his recovery.

[Ron Harvot]

Re: Lambda free light chain level increasing

by Ron Harvot on Tue Jan 26, 2016 4:56 pm

It means nothing. Your husband has all normal readings. If, after a series of tests over a few months, his numbers are outside of normal and continue to rise, then – and only then – could that mean something more dire. As of now, enjoy the normal numbers and try and not worry about it.

[JPC]

Re: Lambda free light chain level increasing

by JPC on Tue Jan 26, 2016 6:03 pm

I will agree with Ron and add that, post stem cell transplant, as the new bone marrow is kicking in, I hear and understand that numbers fluctuate wildly. At about 80 to 100 days, doctors look at the numbers for the first time, usually, but they advise that the numbers may still be subject to significant change for a couple of more months. Thereafter the numbers do settle down.