I'm new to this board. My mum has multiple myeloma. She's 63 and has had it for 9 years now (shes a fighter!) Over that time, she's been on almost all the myeloma drugs, including thalidomide, Revlimid, dexamethasone, and Velcade, etc., etc.. Her levels have been kept at a manageable level for all this time. At diagnosis she had a big hit of cyclophosphamide and a stem cell transplant, etc. (9 years ago).Shes been on a majority of the traditional treatments every week ever since. She's had many, many "bone lesion" (hotspots) throughout this time.
Three weeks ago an ambulance was called as virtually overnight she became unwell. She was diagnosed with pneumonia, neutropenia, low haemoglobin levels, influenza A, and had severe dehydration). It took her body a while to get over the pneumonia and influenza, but she did.
She then had a bunch of tests and scans done and it showed her kidney function was pretty bad and some lesions on her liver were showing on her full body scans.
Shes lost 12 kg (26 lbs) in 3 weeks. In the last 4 days, she's had 2 blood transfusions. We had a meeting with her oncology specialist yesterday. He said apparently her body is no longer responding to treatments, and that apparently liver lesions in multiple myeloma are rare, that her cancer is now aggressive.
She is no longer a candidate for radiation or a stem cell transplant. Apparently her last option now is a super strong hit of Kyprolis, Pomalyst, and dex (KPD).I'm very scared for her. She's super positive, but the specialists couldn't really tell us how things might turn out as it's not a "textbook case" of multiple myeloma.
Pomalyst and Kyprolis have been approved for her case, and will arrive in Australia ready to start in 2 weeks time. They treated her with a cyclophosphamide today, a drug to attempt to help her liver function, etc. They need to keep monitoring her everyday as her levels rose so so quickly.
My question is: In people with relapsed multiple myeloma who have bad kidney function, many bone "hotspots", and have all of a sudden developed organ lesions and a bad protein reading, is the Kyprolis, Pomalyst, and dexamethasone treatment promised to work well still, and be effective still?
I've done a lot if reading in the last day or so as the specialist seems concerned. But I had trouble finding information on the effectiveness of the Kyprolis, Pomalyst, and dexamethasone combination in people like my mum's situation. Is there still hope?
I'm feeling worried as its a lot to understand and process. I'm only 24. But we are being positive for mum. I appreciate any advice, info, comments, etc. Thanks for your help. Sending positive healing vibes to anyone that this disease is affecting right now.
