[JPC]

Kyprolis, Revlimid & dex for high-risk multiple myeloma

by JPC on Wed Sep 07, 2016 8:27 am

For those interested, here an article from the journal Blood that I came across regarding a subgroup analysis of Kyprolis, Revlimid, and dexamethasone (KRd) treatment for high risk cytogenetics, based on the ASPIRE trial. There is a lot of data; however, the bottom line is that Kyprolis helps standard risk as well, but the positive impact in high risk is significant. Here is the reference:

Avet-Loiseau, H., et al., "Carfilzomib significantly improves the progression-free survival of high-risk patients in multiple myeloma," Blood, Sep 2016 (full text of article)

[wemery]

Re: Kyprolis, Revlimid & dex for high-risk multiple myeloma

by wemery on Sat Sep 17, 2016 10:51 am

Thanks for posting this article on Kyprolis, Revlimid and dexamethasone for high-risk multiple myeloma. I'm always interested in any posts for high-risk multiple myeloma. I'm optimistic about the results of this trial and Kyprolis as a potential treatment option for my wife with t(4;14) risk factor.

I was shocked to read that 375 patients in this study had unknown risk factors. Almost half of the study participants did not know the risk status of their multiple myeloma. I realize this study was done in 2010 - 2012, but FISH testing has been available for many years. It seems to me that 100% of patients should be tested for cytogenetic risk. Maybe they are today, I hope so. I believe, understanding the genetics of this disease will help in finding a cure for all patients with multiple myeloma.

[JPC]

Re: Kyprolis, Revlimid & dex for high-risk multiple myeloma

by JPC on Sun Sep 18, 2016 10:36 am

Hi Wayne:

I agree with your comment regarding the FISH test. I recall hearing from a couple of doctors a couple of years ago that you could do the test, but there was no difference in the treatment that would be given, and perhaps some doctor for that reason thought it was not necessary. I think that recently studies have found that certain treatment strategies are doing somewhat of a better job in treating the high risk factors, but of course there is still a lot more to do.

Good luck.