Hello.
I am about to take part in a clinical trial of Kyprolis (carfilzomib) plus dex as a first line of treatment. No other anti-myeloma agents will be involved. I am 60 years old and had been smoldering for 7 years. My myeloma specialist feels that my disease (I have IgA lambda) has progressed enough to begin treatment, though he considers it to be indolent myeloma.
Is anyone out there involved in the current clinical trial or has had experience taking just Kyprolis and dex as a first line of treatment? What was / is your experience in terms of side effects and results? Were / are you also taking bisphosphonates?
Your help would be greatly appreciated.
Olga
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OlgaMM - Name: OMS
- Who do you know with myeloma?: Self
- When were you/they diagnosed?: 2008 - SMM, 2015 - multiple myeloma
- Age at diagnosis: 53
Re: Kyprolis (carfilzomib) - dex clinical trial
Hi Olga,
I'm not aware of a current clinical trial that uses only Kyprolis for smoldering multiple myeloma. The only ones I know of also use lenalidomide (Revlimid). Which trial are you participating in?
I'm not aware of a current clinical trial that uses only Kyprolis for smoldering multiple myeloma. The only ones I know of also use lenalidomide (Revlimid). Which trial are you participating in?
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Multibilly - Name: Multibilly
- Who do you know with myeloma?: Me
- When were you/they diagnosed?: Smoldering, Nov, 2012
Re: Kyprolis (carfilzomib) - dex clinical trial
Hello, Multibilly.
The trial is for multiple myeloma patients who have not been previously treated. It is the Car-BiRD trial at Weill-Cornell Medical College in New York. The specialist believes I qualify for the trial, which would mean I have full-blown multiple myeloma.
But you make a good point. Perhaps the "indolent myeloma" label applied before all the test results were back. It is one of the questions I have for the doctor.
Olga
The trial is for multiple myeloma patients who have not been previously treated. It is the Car-BiRD trial at Weill-Cornell Medical College in New York. The specialist believes I qualify for the trial, which would mean I have full-blown multiple myeloma.
But you make a good point. Perhaps the "indolent myeloma" label applied before all the test results were back. It is one of the questions I have for the doctor.
Olga
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OlgaMM - Name: OMS
- Who do you know with myeloma?: Self
- When were you/they diagnosed?: 2008 - SMM, 2015 - multiple myeloma
- Age at diagnosis: 53
Re: Kyprolis (carfilzomib) - dex clinical trial
Olga,
OK, now I get it. You will start off on Kyprolis + dex and then graduate to BiRD:
"A Phase II Study of Sequential Carfilzomib, Clarithromycin, Lenalidomide, and Dexamethasone (Car-BiRD) Therapy for Subjects with Newly Diagnosed Multiple Myeloma"
Are you decided on whether you would take the trial's transplant option or instead go on to maintenance?
I know there are quite a few folks on this forum that have some experience with carfilzomib (Kyprolis), so I hope you get some good responses on their reactions to it.
Best of luck with this trial and thanks for participating in it.
OK, now I get it. You will start off on Kyprolis + dex and then graduate to BiRD:
"A Phase II Study of Sequential Carfilzomib, Clarithromycin, Lenalidomide, and Dexamethasone (Car-BiRD) Therapy for Subjects with Newly Diagnosed Multiple Myeloma"
Are you decided on whether you would take the trial's transplant option or instead go on to maintenance?
I know there are quite a few folks on this forum that have some experience with carfilzomib (Kyprolis), so I hope you get some good responses on their reactions to it.
Best of luck with this trial and thanks for participating in it.
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Multibilly - Name: Multibilly
- Who do you know with myeloma?: Me
- When were you/they diagnosed?: Smoldering, Nov, 2012
Re: Kyprolis (carfilzomib) - dex clinical trial
Hello again, Multibilly.
I have not really thought so far ahead as to consider whether or not I would have a transplant at the end of the trial. I'm afraid my head is still spinning from my having gone from smoldering to needing treatment just 3 weeks ago.
Thank you for your good wishes.
Olga
I have not really thought so far ahead as to consider whether or not I would have a transplant at the end of the trial. I'm afraid my head is still spinning from my having gone from smoldering to needing treatment just 3 weeks ago.
Thank you for your good wishes.
Olga
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OlgaMM - Name: OMS
- Who do you know with myeloma?: Self
- When were you/they diagnosed?: 2008 - SMM, 2015 - multiple myeloma
- Age at diagnosis: 53
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