Interested in how many rounds of Carfilzomib (combo or single) it took before you started to have a response and what kind of response you ultimately achieved, as in VGPR, CR, etc..
Very interested to know if anyone had increased M Spike during early rounds of Kyprolis (carfilzomib) and had the M Spike decrease in later rounds.
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Re: Kyprolis (carfilzomib) - response to treatment
Hi Classic Kate,
When my husband was first diagnosed almost 3 years ago, he had numerous lesions, anemia, and his M spike was either 5.1 or 4.9 depending on the lab. He had one bone marrow biopsy (BMB) from the initial oncologist who diagnosed him, and a second about a month later when he first saw the myeloma specialists at the University of Michigan, but had had no treatment yet.
He began a clinical study taking carfilzomib [Kyprolis], Revlimid and dexamethasone and was on the combination for a total of 24 months. His M spike dropped dramatically the first few months and he was VGPR by the fourth month. Around the sixth month, his M spike continued to drop, but more slowly. From approximately 18 months to 24 months, it stayed at 0.1.
He was then put on just Revlimid and, finally about 3 months after that, he reached 0.0 and has remained there since then. He had another BMB and flow cytometry and neither one showed any monoclonal plasma cells. He also has had a normal FLC ratio, so I think he is considered to have a SCR.
He never had any increase in M spike, but the decrease just seemed to get smaller at a snail's pace for such a long time. As his treatment continued, we were told not to expect such dramatic decreases as he had at first, and that even in the 23 and 24th month it could still drop.
Best wishes to you.
Chris M
When my husband was first diagnosed almost 3 years ago, he had numerous lesions, anemia, and his M spike was either 5.1 or 4.9 depending on the lab. He had one bone marrow biopsy (BMB) from the initial oncologist who diagnosed him, and a second about a month later when he first saw the myeloma specialists at the University of Michigan, but had had no treatment yet.
He began a clinical study taking carfilzomib [Kyprolis], Revlimid and dexamethasone and was on the combination for a total of 24 months. His M spike dropped dramatically the first few months and he was VGPR by the fourth month. Around the sixth month, his M spike continued to drop, but more slowly. From approximately 18 months to 24 months, it stayed at 0.1.
He was then put on just Revlimid and, finally about 3 months after that, he reached 0.0 and has remained there since then. He had another BMB and flow cytometry and neither one showed any monoclonal plasma cells. He also has had a normal FLC ratio, so I think he is considered to have a SCR.
He never had any increase in M spike, but the decrease just seemed to get smaller at a snail's pace for such a long time. As his treatment continued, we were told not to expect such dramatic decreases as he had at first, and that even in the 23 and 24th month it could still drop.
Best wishes to you.
Chris M
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Chris M
Re: Kyprolis (carfilzomib) - response to treatment
Chris, Thanks. Appreciate the details in your response. Great news about your husband's response. Seems carfilzomib [Kyprolis] can take its time. Thanks again.
Anyone else?
Anyone else?
Re: Kyprolis (carfilzomib) - response to treatment
ClassicKate,
I'm guessing from your question that you are currently on Carflizombib and not seeing the kind of change you were hoping for at this stage?
I'm guessing from your question that you are currently on Carflizombib and not seeing the kind of change you were hoping for at this stage?
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Multibilly - Name: Multibilly
- Who do you know with myeloma?: Me
- When were you/they diagnosed?: Smoldering, Nov, 2012
Re: Kyprolis (carfilzomib) - response to treatment
Hi Multibilly,
Yes, you are correct. I am not responding yet to Round 3 of CCd. Do you have any related data as to when Carfilzomib "kicks" in, if ever?
Thanks, Kate
Yes, you are correct. I am not responding yet to Round 3 of CCd. Do you have any related data as to when Carfilzomib "kicks" in, if ever?
Thanks, Kate
Re: Kyprolis (carfilzomib) - response to treatment
Hi Kate,
There was information presented at the recent ASH meeting about Kyprolis, cyclophosphamide, and dexamethasone in newly diagnosed myeloma patients. Here is a link to the abstract.
https://myelomabeacon.org/resources/mtgs/ash2013/abs/685/
The page also contains a link to the presentation that was given.
https://myelomabeacon.org/docs/ash2013/685.pdf
See the slide about "Time to best response" for information similar to what you're looking for.
Is this your first treatment for myeloma? If so, the data discussed in the abstract should be particularly helpful to you. If you are being treated for a relapse, then the data from the presentation should be intrepreted more carefully.
Hope this helps.
There was information presented at the recent ASH meeting about Kyprolis, cyclophosphamide, and dexamethasone in newly diagnosed myeloma patients. Here is a link to the abstract.
https://myelomabeacon.org/resources/mtgs/ash2013/abs/685/
The page also contains a link to the presentation that was given.
https://myelomabeacon.org/docs/ash2013/685.pdf
See the slide about "Time to best response" for information similar to what you're looking for.
Is this your first treatment for myeloma? If so, the data discussed in the abstract should be particularly helpful to you. If you are being treated for a relapse, then the data from the presentation should be intrepreted more carefully.
Hope this helps.
-
JimNY
Re: Kyprolis (carfilzomib) - response to treatment
Thanks Chris and Jim,
Chris, your husband's experience helped me a lot. Jim, your links are exactly what I was looking for and I will heed your advice since I have had previous treatment.
Thanks so much, Kate
Chris, your husband's experience helped me a lot. Jim, your links are exactly what I was looking for and I will heed your advice since I have had previous treatment.
Thanks so much, Kate
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