My recent blood test indicates:
Normal full Blood count (Hgb 15.7)
Normal renal biochemistry (Cr 82)
Normal bone biochemistry
Total urinary protein 0.16 g/l
SFLC Kappa: 267, Lambda: 9, Ratio: K:L 30
No paraprotein detected
Global hypogammaglobulinaemia
IgA 0.39, IgG 4.4, IgM 0.11
Normal skeletal survey
Since December 2014, the results are stable. Haematologist suggests very rare condition of MGUS. Does anyone come across this type of condition?
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rupasiri - Name: Rupa
- Who do you know with myeloma?: Myself
- When were you/they diagnosed?: December 2014
- Age at diagnosis: 65
Re: Kappa light chain MGUS
Welcome to the forum.
I don't know how rare light-chain MGUS is, but I don't think it's necessarily very rare. I think what makes your situation particularly unique is the fact that all your three major immunoglobulins are below the normal range.
The immunoglobulin normal ranges are:
IgG 767-1,590 mg/dL = 0.767 - 1.590 g/dL = 7.67 - 15.90 g/L
IgA 61-356 mg/dL = 0.061-0.356 g/dL = 0.61-3.56 g/L
IgM 37-286 mg/dL = 0.037-0.286 g/dL = 0.37-2.86 g/L
(I hope I did those unit conversions correctly. I used 1 g = 1000 mg and 1 l = 10 dL.)
So, assuming that your immunoglobulin levels were measured in g/L, it looks your IgA, IgG, and IgM levels are all below their normal ranges. Something, it seems, is suppressing your bone marrow function.
Have you had a bone marrow biopsy? If so, what was your bone marrow plasma cell percentage? Are you on any medications, or do you have any other medical condition, that would cause your immunoglobulin production to be suppressed?
In multiple myeloma patients, you will sometimes see underproduction of some immunoglobulins (a condition sometimes described as "immunoparesis") because the myeloma cells in the bone marrow are "crowding out" the normal cells that produce immunoglobulin. So it would be useful to make sure something like that isn't happening in your case.
As you probably know, MGUS rarely progresses to more serious malignant conditions such as multiple myeloma, which require treatment. Across all MGUS patients, the risk of progression is only about 1 percent per year. There are variations in the risk of progression, however, across MGUS patients, depending on characteristics of their disease. This discussion here in the forum is a useful introduction to some of the factors that affect that risk of progression, with a specific focus on light chain MGUS:
https://myelomabeacon.org/forum/light-chain-mgus-risk-of-progression-t4751.html
One final word of advice would be a suggestion that, if you haven't already done so, it probably would be helpful to be seen by a doctor who specialises in plasma cell disorders. This often isn't viewed as particularly important for MGUS, but your case seems unique enough to merit review by a specialist.
Cheers!
I don't know how rare light-chain MGUS is, but I don't think it's necessarily very rare. I think what makes your situation particularly unique is the fact that all your three major immunoglobulins are below the normal range.
The immunoglobulin normal ranges are:
IgG 767-1,590 mg/dL = 0.767 - 1.590 g/dL = 7.67 - 15.90 g/L
IgA 61-356 mg/dL = 0.061-0.356 g/dL = 0.61-3.56 g/L
IgM 37-286 mg/dL = 0.037-0.286 g/dL = 0.37-2.86 g/L
(I hope I did those unit conversions correctly. I used 1 g = 1000 mg and 1 l = 10 dL.)
So, assuming that your immunoglobulin levels were measured in g/L, it looks your IgA, IgG, and IgM levels are all below their normal ranges. Something, it seems, is suppressing your bone marrow function.
Have you had a bone marrow biopsy? If so, what was your bone marrow plasma cell percentage? Are you on any medications, or do you have any other medical condition, that would cause your immunoglobulin production to be suppressed?
In multiple myeloma patients, you will sometimes see underproduction of some immunoglobulins (a condition sometimes described as "immunoparesis") because the myeloma cells in the bone marrow are "crowding out" the normal cells that produce immunoglobulin. So it would be useful to make sure something like that isn't happening in your case.
As you probably know, MGUS rarely progresses to more serious malignant conditions such as multiple myeloma, which require treatment. Across all MGUS patients, the risk of progression is only about 1 percent per year. There are variations in the risk of progression, however, across MGUS patients, depending on characteristics of their disease. This discussion here in the forum is a useful introduction to some of the factors that affect that risk of progression, with a specific focus on light chain MGUS:
https://myelomabeacon.org/forum/light-chain-mgus-risk-of-progression-t4751.html
One final word of advice would be a suggestion that, if you haven't already done so, it probably would be helpful to be seen by a doctor who specialises in plasma cell disorders. This often isn't viewed as particularly important for MGUS, but your case seems unique enough to merit review by a specialist.
Cheers!
Re: Kappa light chain MGUS
Thank you very much for your kind advice.
My consultant suggested not to have a bone marrow biopsy at this stage. He said follow-up is the best option.
I have had Type 2 diabetes for the last 15 years and it is well controlled. I am extremely well. I had a blood test last week. When I get that, I will post the result. You can have a look.
Once again, I highly appreciate your quick response.
My consultant suggested not to have a bone marrow biopsy at this stage. He said follow-up is the best option.
I have had Type 2 diabetes for the last 15 years and it is well controlled. I am extremely well. I had a blood test last week. When I get that, I will post the result. You can have a look.
Once again, I highly appreciate your quick response.
-
rupasiri - Name: Rupa
- Who do you know with myeloma?: Myself
- When were you/they diagnosed?: December 2014
- Age at diagnosis: 65
3 posts
• Page 1 of 1