[kongfranon]

Kappa free light chain a little high

by kongfranon on Mon Jun 20, 2016 2:26 pm

Hi,

I have been dealing with unexplained neuropathy and nerve issues for the past few months. They ran a series of blood tests and the only thing that came back abnormal was immuno­globulin G and kappa free light chain.

Kappa free light chain was 2.34 mg/dL,

So both only hit a little high. Is this something I need to worry about and follow up on? I do have a referral for a hematologist, I think they just want to play it safe.

Thanks

Protein,Total 7.8 g/dL 6.1 - 7.9 g/dL
Albumin 5.1 g/dL 2.6 - 5.7 g/dL
Serum Albumin % 65.8 % %
Alpha-1-Globulin 0.2 g/dL 0.1 - 0.4 g/dL
Serum Alpha 1 % 2.4 % %
Alpha-2-Globulin 0.7 g/dL 0.3 - 1.1 g/dL
Serum Alpha 2 % 8.8 % %
Serum Beta 0.8 g/dL 0.3 - 1.3 g/dL
Serum Beta % 10.0 % %
Gamma Globulin 1.0 g/dL 0.6 - 1.9 g/dL
Serum Gamma % 13.0 % %

IgG,Serum 1370 mg/dL High 639 - 1349 mg/dL
IgG,Serum 284 mg/dL 70 - 312 mg/dL
IgG Serum 69 mg/dL 56 - 352 mg/dL

Kappa, Free Light Chain 2.34 mg/dL High 0.33 - 1.94 mg/dL
Lambda, Free Light Chain 2.03 mg/dL 0.57 - 2.63 mg/dL
Kappa/Lambda FLC Ratio 1.15 0.26 - 1.65

[Multibilly]

Re: Kappa free light chain a little high

by Multibilly on Mon Jun 20, 2016 8:47 pm

Did they also run a serum immunofixation test? If so, what were the results of that test?

[kongfranon]

Re: Kappa free light chain a little high

by kongfranon on Tue Jun 21, 2016 11:30 am

Thanks for responding, all these test results and names are confusing, but I think this is it? I am not 100% sure:

SIFE+ INTERP

Comment: Using anti-gamma, -alpha, -mu, -kappa and -lambada sera, monoclonal protein is not detected.

Interpretation: M-protein not detected.

PEP S INTERP PROFESSIONAL

The serum fractions are within normal limits and peaks appear normal in shape

InterpretationL Normal electrophoretic pattern.

[Multibilly]

Re: Kappa free light chain a little high

by Multibilly on Tue Jun 21, 2016 7:12 pm

That's great that the SIFE came back as negative. Because your SIFE is negative, the elevated IgG and kappa could be due to a polyclonal protein increase caused by something as simple as an infection. While I'm not a doc, the common approach under these circumstances is simply to get re-tested in a couple of months to see if the values normalize. Have you seen a neurologist about your neuropathy?

[kongfranon]

Re: Kappa free light chain a little high

by kongfranon on Tue Jun 21, 2016 10:54 pm

That is great to know, thanks!

Yeah, I have seen 2 neurologists so far and just been referred to another, so will be my 3rd. So far both gave a diag­nosis of peripheral neurop­athy, but can't find a cause yet. They do think it is possibly autoimmune-related, since the only thing that has worked to take away all symp­toms is an 8-day supply of prednisone, but so far have no real evidence since all tests came back ok, other than the results I posted above. This is all started about 5 months ago out of the blue, with numb­ness in all extremities, then pain, tingling, burning.

Do you think I should still see the hematologist? Or would that just be a waste of a time?

Thanks

[Multibilly]

Re: Kappa free light chain a little high

by Multibilly on Wed Jun 22, 2016 7:42 pm

With the exception of couple of folks, none of us are doctors on this forum. So, I would keep the appointment with the hematologist to get his/her professional take on the situation.

Some additional advice along these lines would be to seek out a hematologist who is a true multiple myeloma specialist. If you let us know what city you are in, folks on this site can likely make some recommendations of doctors and/or specific facilities to seek out. It might also be helpful to go to a large research clinic like the Mayo or Dana Farber that would have multiple specialists that could confer on your case and maybe get to the root cause of your neuropathy more quickly.

[kongfranon]

Re: Kappa free light chain a little high

by kongfranon on Wed Jun 22, 2016 10:08 pm

Thanks for your help.

I am in New York City and was referred to a hematologist-oncologist at New York - Presbyterian. I have an appointment with the physician in July.

I have been seeing some of the top neurologists, and am going to see one more that I was referred to.

[Sorrentostan]

Re: Kappa free light chain a little high

by Sorrentostan on Thu Jun 23, 2016 9:12 am

It is the ratio between kappa and lambda that is the most important, about one and a half to one! Mate, go to sleep with comfort. My kappa is presently over 600 while my lambda has never moved over 10 years from around 10. Your numbers are perfect! Moreover, remember that serum free light chain tests are not absolute! Save your money on the hematologist.