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Is CRP blood test always elevated at the diagnosis time?

by satra on Fri Mar 13, 2015 2:03 pm

Hi,
I am new here. I have not been diagnosed yet.
I suffer from severe bone pain, - knees, elbows, arms, feet and my back. It's going on for 6 months already. They can't find the reason. Been to various doctors - rheumatologist, neurologist, etc.
Had an MRI of my brain done for Polypheral Neuropathy suspicion (turned out normal).
EMG test is normal too, Recently I came back from skiing vacation and my rib started to hurt and did so for about a month after it, without me even remembering how I've hit it.
All blood tests are normal, except for Fe - Iron (44 micg/dl where the normal range is is 60-180). Hemoglobin is low, but still within the norm (12 g/dl where a norm is 12-16). Calcium is 9.2 mg/dl (8.1-10.4)
I am concerned that I might have multiple myeloma.
I would like to ask you guys if from your experience CRP always has to be elevated when multiple myeloma is diagnosed? Was it elevated for you/your loved ones?
My CRP is normal (<0.5 mg/dl). Is it a reliable factor to rule out multiple myeloma?
Appreciate any answer as I am scared!
Julia

satra

Re: Is CRP blood test always elevated at the diagnosis time?

by Multibilly on Fri Mar 13, 2015 3:20 pm

Satra,

One wouldn't use the CRP level to diagnose the presence of multiple myeloma and it won't necessarily be elevated if you have multiple myeloma (I am smoldering and my CRP level is quite normal at 0.026 mg/dL).

If you have a suspicion of multiple myeloma, you would ask for a few basic basic blood tests such as a serum Immonofixation (IFE) and a Serum Protein Electrophoresis (SPEP) as a first step. For good measure, you would also test your immunoglobulin (IgG, IgA, etc) levels and do a Freelite assay. Most of the time, the IFE and SPEP will tell you if you might have some stage of multiple myeloma. In the meantime, you might also want to look at your protein and globulin levels on your Comprehensive Metabolic Panel (CMP) to see if they might be elevated.

I might suggest seeking out a hematologist and maybe one that specializes in multiple myeloma to help with your diagnosis.

Multibilly
Name: Multibilly
Who do you know with myeloma?: Me
When were you/they diagnosed?: Smoldering, Nov, 2012


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