Hi everyone,
I just received my test results and need some help understanding them. See results below.
Kappa / Lambda Light Chains
Kappa 248 - IN RNAGE
LAMBDA 204 - High
Kappa / lambda ratio - low
Total protein / creatine 34 In range
Protein electrophoresis.
Albumin 100
Alpha 1 globulins 0
Alpha 2 globulins 0
Beta globulins 0
Abnormal protein band 1 - no m spike detected.
Interpretation - no abnormal peaks are detected.
Kappa / lambda light chains free with ratio - urine
Kappa free light chains 1.92 - in range
Lambda light chains .31 - in range
Kappa/lambda light chains free ratio - urine - 6.19 - in range.
What does all of this mean?
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Re: Just got initial lab results back - need some help
Are you sure you posted the serum freelite chains numbers correctly? Please always include units of measure with your lab results.
Kappa / Lambda Light Chains
Kappa 248 - IN RNAGE
LAMBDA 204 - High
Kappa / lambda ratio - low
Normal ranges for serum freelite chain assay is:
Lambda FLC (0.57-2.63 mg/dL)
Kappa FLC (0.33 to 1.94 mg/dL)
K/L FLC Ratio (normal is 0.26-1.65)
Assuming you are using different units of measure that changes the reference numbers by a factor of 100, your own numbers would show that your Lambda is normal and your kappa is out of range ... the opposite of what you say here.
Kappa / Lambda Light Chains
Kappa 248 - IN RNAGE
LAMBDA 204 - High
Kappa / lambda ratio - low
Normal ranges for serum freelite chain assay is:
Lambda FLC (0.57-2.63 mg/dL)
Kappa FLC (0.33 to 1.94 mg/dL)
K/L FLC Ratio (normal is 0.26-1.65)
Assuming you are using different units of measure that changes the reference numbers by a factor of 100, your own numbers would show that your Lambda is normal and your kappa is out of range ... the opposite of what you say here.
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Multibilly - Name: Multibilly
- Who do you know with myeloma?: Me
- When were you/they diagnosed?: Smoldering, Nov, 2012
Re: Just got initial lab results back - need some help
My test results look the same way. I had MGUS for 8 years so what I think these numbers represent is the old electrophoretic scan that was executed with the Immunofixation, then the second set of numbers referenced is the newer FLC assay results, which are now a mainstream measurement for disease burden.
I don't know the name of the test because all my results look as though they are stand alone tests and are not labeled but the reference range is in grams per diluted liter. Once I started having the FLC Assay done, it reflected a normal ratio but for 8 years, and as recently as August last year, I have had a count of Kappa and Lambda outside of range with a low ratio. Testing completed in Boston, was the first time I saw both of these tests in the same evaluation results and I was enlightened.
The normal FLC ratio in the assay is a really positive indicator and you should use the results reflected in MG/DL to determine the results of the FLC assay I believe.
I don't know the name of the test because all my results look as though they are stand alone tests and are not labeled but the reference range is in grams per diluted liter. Once I started having the FLC Assay done, it reflected a normal ratio but for 8 years, and as recently as August last year, I have had a count of Kappa and Lambda outside of range with a low ratio. Testing completed in Boston, was the first time I saw both of these tests in the same evaluation results and I was enlightened.
The normal FLC ratio in the assay is a really positive indicator and you should use the results reflected in MG/DL to determine the results of the FLC assay I believe.
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jbh
Re: Just got initial lab results back - need some help
Oops, I should have read your first post more carefully.
First off, I'm not a doc, so do check with yours.
In general, test results ought to be labeled or grouped with complete names.
The protein electrophoresis numbers "appear" to be from a urine protein electrophoresis (UPEP)? UPEPs measure freelite chains in your urine, not monoclonal immunoglobulin proteins (which don't show up in your urine).
So, serum FLC measurements are more sensitive than other tests for FLCs. These are normal, and that is therefore encouraging.
Did you have serum protein electrophoresis (SPEP) to measure any potential M-Spike in your blood? This would be the other key lab test to know in regards to any suspect proteins.
Note that immunofixation tests don't tell you the amounts of suspect proteins (it is a qualitative test, not a quantitative test like serum protein electrophoresis is). It just tells you if you have any suspect proteins or not...and what kind they are.
I assume you also had the other standard tests to check out whether your had any anemia or kidney issues going on?
First off, I'm not a doc, so do check with yours.
In general, test results ought to be labeled or grouped with complete names.
The protein electrophoresis numbers "appear" to be from a urine protein electrophoresis (UPEP)? UPEPs measure freelite chains in your urine, not monoclonal immunoglobulin proteins (which don't show up in your urine).
So, serum FLC measurements are more sensitive than other tests for FLCs. These are normal, and that is therefore encouraging.
Did you have serum protein electrophoresis (SPEP) to measure any potential M-Spike in your blood? This would be the other key lab test to know in regards to any suspect proteins.
Note that immunofixation tests don't tell you the amounts of suspect proteins (it is a qualitative test, not a quantitative test like serum protein electrophoresis is). It just tells you if you have any suspect proteins or not...and what kind they are.
I assume you also had the other standard tests to check out whether your had any anemia or kidney issues going on?
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Multibilly - Name: Multibilly
- Who do you know with myeloma?: Me
- When were you/they diagnosed?: Smoldering, Nov, 2012
Re: Just got initial lab results back - need some help
As is mentioned, the units of measure are not given; the most common are mg/L; mg/dL are different by a factor of 10.
If your results are 248mg/L and 204 mg/L then both the kappa and lambda are elevated; if the units are mg/dL then the results would be 24.8mg/dL and 20.4 mgL; either way both are elevated
Your ratio of kappa/lambda or 248/204 is 1.22 which is in the normal range.
If kappa and lambda are both elevated and the ratio normal then this implies that the renal function is not normal; what was your creatinine result?
http://myeloma.org/pdfs/Freelite_tipcard_2011_c1web.pdf ; this is a card from the International Myeloma Foundation on interpreting the Freelite test.
If your results are 248mg/L and 204 mg/L then both the kappa and lambda are elevated; if the units are mg/dL then the results would be 24.8mg/dL and 20.4 mgL; either way both are elevated
Your ratio of kappa/lambda or 248/204 is 1.22 which is in the normal range.
If kappa and lambda are both elevated and the ratio normal then this implies that the renal function is not normal; what was your creatinine result?
http://myeloma.org/pdfs/Freelite_tipcard_2011_c1web.pdf ; this is a card from the International Myeloma Foundation on interpreting the Freelite test.
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bond007
Re: Just got initial lab results back - need some help
First off, I'm a bit confused here. There are different names appearing on each of the comments, yet bond007 states "like I mentioned before..."
I would respectfully take exception to bond007's comments about both of the freelite chain values being out of range on the UPEP results that dolphins4life first posted. UPEP results are not necessarily standardized like the serum freelite chain results are. So, the interpretation of the UPEP results depends on the lab equipment and their own unique reference ranges and what the lab report states are valid ranges. Again the Serum FLCs appear normal and serum Freelite (R) test results are all standardized across the industry...and the serum Freelite chain test is more accurate than the UPEP FLC test.
The bottom line is I would suggest that dophins4life discuss all this with his doc
I would respectfully take exception to bond007's comments about both of the freelite chain values being out of range on the UPEP results that dolphins4life first posted. UPEP results are not necessarily standardized like the serum freelite chain results are. So, the interpretation of the UPEP results depends on the lab equipment and their own unique reference ranges and what the lab report states are valid ranges. Again the Serum FLCs appear normal and serum Freelite (R) test results are all standardized across the industry...and the serum Freelite chain test is more accurate than the UPEP FLC test.
The bottom line is I would suggest that dophins4life discuss all this with his doc
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Multibilly - Name: Multibilly
- Who do you know with myeloma?: Me
- When were you/they diagnosed?: Smoldering, Nov, 2012
Re: Just got initial lab results back - need some help
Yes ... that does appear to be urine on the bottom set. I missed that; sorry. My old tests do look just like the numbers reflected on the top of this report and NOT the new FLC assay results.
Recently though, both of my tests were serum and one was attached to the immunofixation report and it simply said, "Ig Free Light Chains". The other says "FLC Assay". Two different sets of numbers with different results from specimens taken on the same day.
I'll look into this more or ask my doctor next time I see him. Sorry I wasn't able to assist.
Recently though, both of my tests were serum and one was attached to the immunofixation report and it simply said, "Ig Free Light Chains". The other says "FLC Assay". Two different sets of numbers with different results from specimens taken on the same day.
I'll look into this more or ask my doctor next time I see him. Sorry I wasn't able to assist.
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jbh
Re: Just got initial lab results back - need some help
Thanks for everyone´s input. I really appreciate it.
This journey all started off with unexplained bilateral pain in my thighs. It gets bad sometimes preventing me from doing anything that involves walking or standing. I have not been able to go to the gym in over 7 months. It´s frustrating.
I was wondering if peripheral neuropathy could be a symptom of multiple myeloma.
Also, when I hear people talking about paraprotein where in the blood tests would I be able to see my levels of paraprotein?
This journey all started off with unexplained bilateral pain in my thighs. It gets bad sometimes preventing me from doing anything that involves walking or standing. I have not been able to go to the gym in over 7 months. It´s frustrating.
I was wondering if peripheral neuropathy could be a symptom of multiple myeloma.
Also, when I hear people talking about paraprotein where in the blood tests would I be able to see my levels of paraprotein?
8 posts
• Page 1 of 1