My mom who is currently in multiple myeloma remission has started complaining of pains in ribs (same indication which she cited during initial Multiple myeloma occurrence).
Protein electrophoresis indicates that there is no M band.
Beta 2 Microblobulin is at 5004 ng/ML (clinical acceptable levels are at 2366 ng/mL).
Doctors have said that no treatment can be administered until M band is found? Her Kidney function is normal as well.
Should I be worried? Some articles suggest that higher levels of Beta 2 indicates that the Myeloma is progressing.
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Re: Increasing values of beta 2 microglobulin
Aren't they going to do any imaging tests such as PET CT or MRI to investigate the bone pain? These modalities can detect issues in the marrow.
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terryl1 - Name: Terry
- Who do you know with myeloma?: self
- When were you/they diagnosed?: August 10, 2011
- Age at diagnosis: 49
Re: Increasing values of beta 2 microglobulin
The doctors' advice regarding M protein is deficient in that multiple myeloma can evolve to forms that are no longer associated with an M band. For example, they can change to forms associated only with the production of light chains (so called "light chain escape") or no protein at all. (non-secretory). So Terry's suggestion is therefore right on point. Other blood values might be useful as progression indicators, such as Hemoglobin, calcium, and albumin.
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Whatsamatteru
Re: Increasing values of beta 2 microglobulin
Dear Skar,
Increasing beta2-microglobulin levels can be an indicator of the multiple myeloma progressing or evidence that there has been a decline in her kidney function. In the setting of new rib pain, further work-up is in order to rule out the possibility of non-secreotry multple myeloma as a cause of her symptoms. MRI and/or PET-CT would be 2 great ways to get at this.
Good luck andf let us know how things go.
Take care!
Pete V.
Increasing beta2-microglobulin levels can be an indicator of the multiple myeloma progressing or evidence that there has been a decline in her kidney function. In the setting of new rib pain, further work-up is in order to rule out the possibility of non-secreotry multple myeloma as a cause of her symptoms. MRI and/or PET-CT would be 2 great ways to get at this.
Good luck andf let us know how things go.
Take care!
Pete V.
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Dr. Peter Voorhees - Name: Peter Voorhees, M.D.
Beacon Medical Advisor
Re: Increasing values of beta 2 microglobulin
Whatsamatteru wrote:
The doctors' advice regarding M protein is deficient in that multiple myeloma can evolve to forms that are no longer associated with an M band. For example, they can change to forms associated only with the production of light chains (so called "light chain escape") or no protein at all. (non-secretory). So Terry's suggestion is therefore right on point. Other blood values might be useful as progression indicators, such as Hemoglobin, calcium, and albumin.
Many thanks for your response. I was unaware of non-secretory multiple myeloma.
Her blood numbers were in range
Hemoglobin 12.4 g/dL
Createnine 1.2 mg/DL
Calcium 10.1 mg/dL
Albumin 4.12 g/dL
Things that were out of range
Mean Corpuscular Hemoglobin 26.2 pg (range 27.0 - 32.0)
Mean Corpuscular Volume 80.9 fL (range 83.0 - 101.0)
Red Cell distribution width 14.7 % (range 11.6 to 14.0)
Glycosylated Hemoglobin 6.4 (pre diabetic)
Man Plasma Glucose 137 mg/dL
and
Beta 2 Microblobulin 5004 ng/ML
The doctors' advice regarding M protein is deficient in that multiple myeloma can evolve to forms that are no longer associated with an M band. For example, they can change to forms associated only with the production of light chains (so called "light chain escape") or no protein at all. (non-secretory). So Terry's suggestion is therefore right on point. Other blood values might be useful as progression indicators, such as Hemoglobin, calcium, and albumin.
Many thanks for your response. I was unaware of non-secretory multiple myeloma.
Her blood numbers were in range
Hemoglobin 12.4 g/dL
Createnine 1.2 mg/DL
Calcium 10.1 mg/dL
Albumin 4.12 g/dL
Things that were out of range
Mean Corpuscular Hemoglobin 26.2 pg (range 27.0 - 32.0)
Mean Corpuscular Volume 80.9 fL (range 83.0 - 101.0)
Red Cell distribution width 14.7 % (range 11.6 to 14.0)
Glycosylated Hemoglobin 6.4 (pre diabetic)
Man Plasma Glucose 137 mg/dL
and
Beta 2 Microblobulin 5004 ng/ML
Re: Increasing values of beta 2 microglobulin
Terryl1 wrote:
Aren't they going to do any imaging tests such as PET CT or MRI to investigate the bone pain? These modalities can detect issues in the marrow.
Thanks terry, I will insist on getting the imaging tests.
Aren't they going to do any imaging tests such as PET CT or MRI to investigate the bone pain? These modalities can detect issues in the marrow.
Thanks terry, I will insist on getting the imaging tests.
Re: Increasing values of beta 2 microglobulin
Dr. Peter Voorhees wrote:
Dear Skar,
Increasing beta2-microglobulin levels can be an indicator of the multiple myeloma progressing or evidence that there has been a decline in her kidney function. In the setting of new rib pain, further work-up is in order to rule out the possibility of non-secreotry multple myeloma as a cause of her symptoms. MRI and/or PET-CT would be 2 great ways to get at this.
Good luck andf let us know how things go.
Take care!
Pete V.
-------------------------------------------------
Many thanks Dr Pete. I will have the MRI and/or PET-CT scan done to rule out possibility of non-secretory multiple myeloma. I will let you know the outcome of tests.
Dear Skar,
Increasing beta2-microglobulin levels can be an indicator of the multiple myeloma progressing or evidence that there has been a decline in her kidney function. In the setting of new rib pain, further work-up is in order to rule out the possibility of non-secreotry multple myeloma as a cause of her symptoms. MRI and/or PET-CT would be 2 great ways to get at this.
Good luck andf let us know how things go.
Take care!
Pete V.
-------------------------------------------------
Many thanks Dr Pete. I will have the MRI and/or PET-CT scan done to rule out possibility of non-secretory multiple myeloma. I will let you know the outcome of tests.
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