Hi everybody,
I received the results of a serum immunofixation test. The report says immunoglobulinopathy IgG Kappa lambda. Do you know what does it mean? Urine immunofixation and serum free light chains are negative. Thank you.
Best regards,
Jill
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Re: Immunoglobulinopathy IgG kappa lambda?
What this says is that on the serum immunofixation test there was identified as an over produciton of IgG immuogobulin. However the Urine test did not have the same result. Furthermore no sign of unusual light chains. The freel light chain asay normall would show the overproduction of either the lamda or kappa light chains in the IgG immunugoblin. The fact that the test was normal is great news.
Did they do a SPEP test as well? The SPEP is used to measure the amount of any over production of the IgG immunogobulin. It is often referred to as an M spike.
Right now it sounds like you are ok but if they did a SPEP you should get access to those results as well. They usually order the SPEP when they do the immunofixation test. If it is also negative then the likelihood of you having multiple myeloma is slim.
Are you experiencing any bone pain or fatigue? Why did they run the tests? Those tests are specific for multiple myeloma so they must have had some suspicion.
Ron
Did they do a SPEP test as well? The SPEP is used to measure the amount of any over production of the IgG immunogobulin. It is often referred to as an M spike.
Right now it sounds like you are ok but if they did a SPEP you should get access to those results as well. They usually order the SPEP when they do the immunofixation test. If it is also negative then the likelihood of you having multiple myeloma is slim.
Are you experiencing any bone pain or fatigue? Why did they run the tests? Those tests are specific for multiple myeloma so they must have had some suspicion.
Ron
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Ron Harvot - Name: Ron Harvot
- Who do you know with myeloma?: Myself
- When were you/they diagnosed?: Feb 2009
- Age at diagnosis: 56
Re: Immunoglobulinopathy IgG kappa lambda?
Hi Ron,
I was diagnosed with multiple myeloma about 2 years ago. I had 3 cycles of chemo and a stem cell transplant and then I went into remission. These tests were done because of the scheduled myeloma specific follow ups. SPEP and UPEP were both negative. The problem is how can the serum immunofixation be positive if everything else if negative? I am diagnosed with IgG kappa light chain myeloma and normally is followed by sFLC. Thanks
Best regards
Jill
I was diagnosed with multiple myeloma about 2 years ago. I had 3 cycles of chemo and a stem cell transplant and then I went into remission. These tests were done because of the scheduled myeloma specific follow ups. SPEP and UPEP were both negative. The problem is how can the serum immunofixation be positive if everything else if negative? I am diagnosed with IgG kappa light chain myeloma and normally is followed by sFLC. Thanks
Best regards
Jill
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Anonymous
Re: Immunoglobulinopathy IgG kappa lambda?
Jill,
I too have light chain myeloma. I have IgG kappa light chain multiple myeloma. Every 3 months or so they draw my blood for the Freelite Chain Assay test, the SPEP and immunofixation. Because it is light chain Myeloma I have never had a measurable M spike and my immunofixation shows only a faint IgG kappa marker that is not measurable. That is the nature of light chain myeloma and that is why the light chain assay is so important and, I would suggest, the main test that both you and I need to focus on.
It sounds like you are in a remissive state much the same as I am. Are we disease free with healthy bone marrow? The answer is no. But the disease is being contained at a low, almost non-measurable level.
Good luck and hope you stay in a remissive state.
Ron
I too have light chain myeloma. I have IgG kappa light chain multiple myeloma. Every 3 months or so they draw my blood for the Freelite Chain Assay test, the SPEP and immunofixation. Because it is light chain Myeloma I have never had a measurable M spike and my immunofixation shows only a faint IgG kappa marker that is not measurable. That is the nature of light chain myeloma and that is why the light chain assay is so important and, I would suggest, the main test that both you and I need to focus on.
It sounds like you are in a remissive state much the same as I am. Are we disease free with healthy bone marrow? The answer is no. But the disease is being contained at a low, almost non-measurable level.
Good luck and hope you stay in a remissive state.
Ron
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Ron Harvot - Name: Ron Harvot
- Who do you know with myeloma?: Myself
- When were you/they diagnosed?: Feb 2009
- Age at diagnosis: 56
Re: Immunoglobulinopathy IgG kappa lambda?
Ron, may I ask about the levels of your Kappa FLC? I'm having a major struggle over this. My initial finding was on the free light chain assay & my elevation was 26.74 with the high on the ref. range being 19.40. My ratio was slightly high at 1.68 with the high being 1.65. My labs you referenced were wihin normal ranges. In your opinion based on your experience with FLC myeloma, should I pursue this further? I have varing opinions from the 2 heme's I've seen. My results from Dec. showed Kappa elevated on a different scale of .33-1.94 being normal & I was H at 3.02, but the ratio was normal. I'm not familar with the differing scales & have no idea if I need to be concerned for further opinion or tracking to see what happens going forward. Thank you.
PS... My IGA was elevated, and so was my beta-2-microglobulin serum, yet I was dismissed by the physician who ordered the work up. It's stressful to not feel confident the assessment was in my best interest.
PS... My IGA was elevated, and so was my beta-2-microglobulin serum, yet I was dismissed by the physician who ordered the work up. It's stressful to not feel confident the assessment was in my best interest.
Re: Immunoglobulinopathy IgG kappa lambda?
I think you are doing great. The numbers are going to bounce around a little so the real issue is how do they look over time. The ratios that are commonly published and the ones I am tested under show the following normal ranges: Kappa 3.3-19.4, Lambda 5.71-26.3, K/L Ratio .26-1.65.
With myself, when I was originally diagnosed back in Feb 2009, my Kappa light chain was 95.8 (high) and my Lambda was 2.27 (low). The ratio was 42.2 (high). I was started on VRD and showed immediate improvement. Within 6 months all of my readings were in the normal range. Since then my readings have bounced around a bit but my Kappa level has stayed in the normal range. My last test had the Kappa at 7.4 (normal), Lambda 5.0 (low) and ratio 1.48 (normal). My Kappa chain is the one that is overproduced but it has been in the normal range since Aug 2009 and under 10 since 2011. My lambda is below normal but not as far below normal as it was back when I was diagnosed. The ratio bounces a bit. Sometimes the ratio is just over normal and then the next test it is within the normal range.
In my case the lambda level being a little low is an indication that I don't have completely healthy bone marrow but that is a given with multiple myeloma.. The disease is still present but at a low level.
Ron
In your case IMO, I don't believe there is reason to get concerned unless you start seeing the Kappa level creep up over a period of tests and the ratio climbing out of normal range in sync with the Kappa level.
Ron
With myself, when I was originally diagnosed back in Feb 2009, my Kappa light chain was 95.8 (high) and my Lambda was 2.27 (low). The ratio was 42.2 (high). I was started on VRD and showed immediate improvement. Within 6 months all of my readings were in the normal range. Since then my readings have bounced around a bit but my Kappa level has stayed in the normal range. My last test had the Kappa at 7.4 (normal), Lambda 5.0 (low) and ratio 1.48 (normal). My Kappa chain is the one that is overproduced but it has been in the normal range since Aug 2009 and under 10 since 2011. My lambda is below normal but not as far below normal as it was back when I was diagnosed. The ratio bounces a bit. Sometimes the ratio is just over normal and then the next test it is within the normal range.
In my case the lambda level being a little low is an indication that I don't have completely healthy bone marrow but that is a given with multiple myeloma.. The disease is still present but at a low level.
Ron
In your case IMO, I don't believe there is reason to get concerned unless you start seeing the Kappa level creep up over a period of tests and the ratio climbing out of normal range in sync with the Kappa level.
Ron
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Ron Harvot - Name: Ron Harvot
- Who do you know with myeloma?: Myself
- When were you/they diagnosed?: Feb 2009
- Age at diagnosis: 56
7 posts
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