Since we are now seeing a specialist, we now get the results of all bloodwork done. In looking over my husband's immunofixation results I see that they test for IgG, IgA and IgM. All of those results are BELOW the normal standard range. So would that mean my husband has one of the more rare types such as IgE or IgD?
It also makes me wonder why they do not include those in the test as well?
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Melanie - Name: Melanie
- Who do you know with myeloma?: husband
- When were you/they diagnosed?: July 2014
- Age at diagnosis: 54
Re: All tested immunoglobulin levels below normal - meaning?
Hi Melanie,
A couple of things here.
When you say you are looking at your IgG, IgA levels, etc, I think you mean you are looking at the "quantitative immunolglobulin tests", not the "immunofixation test".
In going through some of your earlier posts, it sounds like your husband has already undergone treatment. Do you know what his various immunogloublin levels were when he was first diagnosed or before the treatment started?
Did he have a measurable M-Spike (aka paraprotein, M-protein, etc) from his Serum Protein Electrophoresis (SPEP) test before treatment? What did his immunofixation test (this will tell you the type of monoclonal protein he has) say before he underwent treatment?
The reason I ask these questions is that he may have what is known as light-chain restricted multiple myeloma, where a specific immunoglobulin (heavy chains) like the IgA doesn't get elevated because there is little or no monoclonal protein (M-Spike) in the patient's blood – only free light chains.
Note that various immunoglobulin levels can also become depressed as a result of a condition called "immunoparesis", which is not uncommon with light-chain restricted multiple myeloma.
A couple of things here.
When you say you are looking at your IgG, IgA levels, etc, I think you mean you are looking at the "quantitative immunolglobulin tests", not the "immunofixation test".
In going through some of your earlier posts, it sounds like your husband has already undergone treatment. Do you know what his various immunogloublin levels were when he was first diagnosed or before the treatment started?
Did he have a measurable M-Spike (aka paraprotein, M-protein, etc) from his Serum Protein Electrophoresis (SPEP) test before treatment? What did his immunofixation test (this will tell you the type of monoclonal protein he has) say before he underwent treatment?
The reason I ask these questions is that he may have what is known as light-chain restricted multiple myeloma, where a specific immunoglobulin (heavy chains) like the IgA doesn't get elevated because there is little or no monoclonal protein (M-Spike) in the patient's blood – only free light chains.
Note that various immunoglobulin levels can also become depressed as a result of a condition called "immunoparesis", which is not uncommon with light-chain restricted multiple myeloma.
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Multibilly - Name: Multibilly
- Who do you know with myeloma?: Me
- When were you/they diagnosed?: Smoldering, Nov, 2012
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