Hi,
I was hoping I could get help on my labs.
M spike 1.3
Immunofixation says monoclonal IgG lambda.
IgA is 81
IgM is low at 22, range is 37-286
IgG is 1240, range is 767 - 1590
Kappa free light chain - low 0.12, range 0.33-1.94
Lambda free light chain - high 4.44, range 0.57-2.63
Kappa/lambda ratio is low .0302, range 0.26-1.65
I'm confused. If my IgM is the one that is low, how come it's called IgG lambda?
Forums
Re: Confused on labs - am I IgG or IgM lambda?
Lennonstar,
First off, I'm not a doc, so please check with one.
But this doesn't sound right. I'm not sure how you could have an IgG level of 1240 mg/dL and an M-spike of 1.3 g/dL (1300 mg/dL) and be of IgG type multiple myeloma. I'm assuming that the M-spike was reported in g/dL??
I'm wondering if they blew your tests (this sometimes happens). Do you have any earlier tests to compare these numbers against?
Uninvolved immunoglobulins (in your case IgM or IgA) can sometimes be suppressed due to a condition called immunoparesis. But this still doesn't explain to me how you could have such a low IgG with this kind of an IgG M-spike level.
BTW, please always include the units of measure when you post any lab results
Different labs use different units of measure.
First off, I'm not a doc, so please check with one.
But this doesn't sound right. I'm not sure how you could have an IgG level of 1240 mg/dL and an M-spike of 1.3 g/dL (1300 mg/dL) and be of IgG type multiple myeloma. I'm assuming that the M-spike was reported in g/dL??
I'm wondering if they blew your tests (this sometimes happens). Do you have any earlier tests to compare these numbers against?
Uninvolved immunoglobulins (in your case IgM or IgA) can sometimes be suppressed due to a condition called immunoparesis. But this still doesn't explain to me how you could have such a low IgG with this kind of an IgG M-spike level.
BTW, please always include the units of measure when you post any lab results
Different labs use different units of measure.-
Multibilly - Name: Multibilly
- Who do you know with myeloma?: Me
- When were you/they diagnosed?: Smoldering, Nov, 2012
Re: Confused on labs - am I IgG or IgM lambda?
Sorry, the M-spike is 1.3 g/dl and all the others are in mg/dl.
Re: Confused on labs - am I IgG or IgM lambda?
Have you discussed these results with your doc?
For IgG Lambda, your total IgG simply measures the sum of your normal IgG and your monoclonal IgG (since it has been determined that you have IgG-type multiple myeloma). So, your IgG M-spike (1300 mg/dL) should be smaller than the 1240 mg/dL total IgG number.
So, that is why I think something isn't right here. But, again, I'm not a doctor.
For IgG Lambda, your total IgG simply measures the sum of your normal IgG and your monoclonal IgG (since it has been determined that you have IgG-type multiple myeloma). So, your IgG M-spike (1300 mg/dL) should be smaller than the 1240 mg/dL total IgG number.
So, that is why I think something isn't right here. But, again, I'm not a doctor.
-
Multibilly - Name: Multibilly
- Who do you know with myeloma?: Me
- When were you/they diagnosed?: Smoldering, Nov, 2012
Re: Confused on labs - am I IgG or IgM lambda?
I guess I am missing something, but the tests all seem to point to IgG lamda multiple myeloma
First, the immunofixation shows IgG lambda
Second, the sFLC assay indicates a high lambda FLC and a low ratio, which is consistent with a lambda type multiple myeloma.
Third, an M spike of 1.3.
All of that is consistent with the diagnosis.
The only inconsistency is in the overall protein analysis, which are heavy chain measurements. But those are secondary to the sFLC and immunofixation insofar as diagnosis, IMO.
I, too, am not a doctor, so I think what you need is an explanation from your oncologist.
Ron
First, the immunofixation shows IgG lambda
Second, the sFLC assay indicates a high lambda FLC and a low ratio, which is consistent with a lambda type multiple myeloma.
Third, an M spike of 1.3.
All of that is consistent with the diagnosis.
The only inconsistency is in the overall protein analysis, which are heavy chain measurements. But those are secondary to the sFLC and immunofixation insofar as diagnosis, IMO.
I, too, am not a doctor, so I think what you need is an explanation from your oncologist.
Ron
-
Ron Harvot - Name: Ron Harvot
- Who do you know with myeloma?: Myself
- When were you/they diagnosed?: Feb 2009
- Age at diagnosis: 56
Re: Confused on labs - am I IgG or IgM lambda?
I went back to make sure I wrote the correct numbers. The m spike is 1.0 not 1.3 that I accidentally wrote and then re-copied wrong when correcting the g and mg. does that make anymore sense. My oncolgist is out of the country and the nurse really confused me.
-
Anonymous
Re: Confused on labs - am I IgG or IgM lambda?
Anonymous,
Are you Lennonstarr? If so, could you please login when you post to this, or other, discussions, so that we know who is posting?
Are you Lennonstarr? If so, could you please login when you post to this, or other, discussions, so that we know who is posting?
Re: Confused on labs - am I IgG or IgM lambda?
An M-spike of 1.0 is better news for you and at least puts the numbers closer to being believable. I also agree with Ron's statement. Nothing here suggests that this wouldn't be IgG lambda-type multiple myeloma. But at the end of the day, neither of us are docs, so you are best advised to consult with your doc.
By the way, IgM multiple myeloma is extremely rare.
By the way, IgM multiple myeloma is extremely rare.
-
Multibilly - Name: Multibilly
- Who do you know with myeloma?: Me
- When were you/they diagnosed?: Smoldering, Nov, 2012
Re: Confused on labs - am I IgG or IgM lambda?
Your numbers are not that far out of normal and therefore what you have may be MGUS and not multiple myeloma. Do you have any other symptoms like bone pain, anemia, kidney problems, fatigue? When your oncologist gets back, you need for him / her to go over in detail your numbers and explain what they mean.
I realize and sympathize with your concern and confusion. I can tell you that multiple myeloma that is IgM lambda is rare and far less common than IgG lambda.
Ron
I realize and sympathize with your concern and confusion. I can tell you that multiple myeloma that is IgM lambda is rare and far less common than IgG lambda.
Ron
-
Ron Harvot - Name: Ron Harvot
- Who do you know with myeloma?: Myself
- When were you/they diagnosed?: Feb 2009
- Age at diagnosis: 56
11 posts
• Page 1 of 2 • 1, 2