[DSMan]

IGG, IGA, IGM results all normal

by DSMan on Tue Nov 19, 2013 11:27 am

My relative IGG, IGA, and IGM results all return back in the normal range, however what was not normal was monoclonal proteins were detected.

They found Free Lambda Proteins migrating in the Alpha-2 and Gamma region, what does this actually mean?

Thanks for any input.

[TerryH]

Re: IGG, IGA, IGM results all normal

by TerryH on Tue Nov 19, 2013 11:31 am

Hi DSMan,

Maybe it's just me, but I think you'll need to provide a little bit more context for your question before we can help.

Have you already been diagnosed with myeloma (or MGUS, or smoldering myeloma) ... and, if so, have you been treated for it in the past?

Or are you undergoing tests to determine if you might have myeloma (or MGUS, etc.)?

[DSMan]

Re: IGG, IGA, IGM results all normal

by DSMan on Tue Nov 19, 2013 11:33 am

Sorry this is for my relative, they have been diagnosed with Multiple Myeloma. No they haven't been treated for it yet. They also have very high levels of Lambda free light chains. I was just wondering what significance does this test result have.

[mowgli18]

Re: IGG, IGA, IGM results all normal

by mowgli18 on Tue Nov 19, 2013 12:46 pm

I have lambda light chain myeloma. Another term is light chain disease. It is where the light chains detect the myeloma but there is no detectable m-spike. That is how they will follow the disease -- with a serum free light chain tests and bone marrow biopsies. The treatment is the same as for other myeloma.

[DSMan]

Re: IGG, IGA, IGM results all normal

by DSMan on Tue Nov 19, 2013 4:58 pm

I believe my grandfather was diagnosed with Lambda Light Chain Multiple Myeloma.

[Dr. Jason Valent]

Re: IGG, IGA, IGM results all normal

by Dr. Jason Valent on Tue Nov 19, 2013 5:35 pm

It appears that the protein electrophoresis were able to pick up the lambda light chain portion of the immunoglobulin. About 10% of multiple myeloma are light chain only disease. The maligant cell does not make an intact immunoglobulin (IgG, IgA, or IgM) but just the light chain portion (either kappa or lambda)