Does anyone know if an increase in igA from 838 to 883 and a decrease in igG from 575 to 544 in 1 months time is significant? I don't think it is but was just wondering.
I also went from a 0 CRP to 7.3 and from an ESR of 9 to 38.
Thanks
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angiebaldy - Name: angiebaldy
- Who do you know with myeloma?: Me
- When were you/they diagnosed?: Sept 2012 MGUS Jan. 2014 SMM
- Age at diagnosis: 47
Re: IgG and igA levels
The i in igA and igG are supposed to be capitalized. Terrible at typing.
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angiebaldy - Name: angiebaldy
- Who do you know with myeloma?: Me
- When were you/they diagnosed?: Sept 2012 MGUS Jan. 2014 SMM
- Age at diagnosis: 47
Re: IgG and igA levels
Hi Angiebaldy,
These changes would not be considered significant and fall within the normal variation that is expected with these tests. It's important to also remember that immunoglobulin levels can go up for reasons completely unrelated to myeloma (e.g. an infection or other form of inflammation). Thus we usually don't make much of 1 value rising, but always look at all of the myeloma blood and urine tests together, and make sure any changes are confirmed on subsequent testing before recommending any new interventions.
These changes would not be considered significant and fall within the normal variation that is expected with these tests. It's important to also remember that immunoglobulin levels can go up for reasons completely unrelated to myeloma (e.g. an infection or other form of inflammation). Thus we usually don't make much of 1 value rising, but always look at all of the myeloma blood and urine tests together, and make sure any changes are confirmed on subsequent testing before recommending any new interventions.
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Dr. Adam Cohen - Name: Adam D. Cohen, M.D.
Beacon Medical Advisor
Re: IgG and igA levels
Thank you Dr. Cohen. I thought so but wanted some reassurance.
Angie
Angie
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angiebaldy - Name: angiebaldy
- Who do you know with myeloma?: Me
- When were you/they diagnosed?: Sept 2012 MGUS Jan. 2014 SMM
- Age at diagnosis: 47
Re: IgG and igA levels
angiebaldy,
I can attest to what Dr. Cohen says about the immunoglobulin levels fluctuating. I have been in CR for almost a year now, and twice my IgA levels have jumped up, then worked their way back down. Once was following a sinus infection last January, the other after a fairly good cold about two months ago. In both cases, it took about two to three months to get back to their previous level. This didn't prevent me from worrying about it though until I got that next lab result showing it was coming back down.
I can attest to what Dr. Cohen says about the immunoglobulin levels fluctuating. I have been in CR for almost a year now, and twice my IgA levels have jumped up, then worked their way back down. Once was following a sinus infection last January, the other after a fairly good cold about two months ago. In both cases, it took about two to three months to get back to their previous level. This didn't prevent me from worrying about it though until I got that next lab result showing it was coming back down.
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Kevin J - Name: Kevin J
- Who do you know with myeloma?: myself
- When were you/they diagnosed?: Jan 2011
- Age at diagnosis: 52
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