[rosas]

Can IgG and IgA increase together at the same time?

by rosas on Wed Dec 16, 2015 11:17 am

Good Morning,

I am helping family member and wanted to get suggestions before we go to the specialist.

Does anyone know if IgG and IgA increase together?

This the lab results, any help would be appreciated! We are confused and did not anticipate these tests. My family member was being tested for infections (which we are still not sure if this is the case). We are worried.

Immunoglobulins

IgG, Blood 700-1600 mg/dL 2077 (thier result)
IgA, Blood 70-400 mg/dL 1149 (their result)
IgM, Blood 40-230 mg/dL 230 (their result)

Serum Protein Electrophoresis

Component Std Range Your Value
Total Protein 6.0-8.2 g/dL 8.3
Albumin 3.2-4.8 g/dL 3.1
Monoclonal Peak 0.14 g/dL

Interpretation Path:

Monoclonal IgM kappa. Increased gamma globulins.

CBC is good except Lymps are a bit low.

[Multibilly]

Re: Can IgG and IgA increase together at the same time?

by Multibilly on Wed Dec 16, 2015 2:00 pm

Hi Rosas,

Welcome to the forum!

First off, I'm not a doc, so please have the patient check all this with their doctor.

The increased IgA and IgG levels can be due to a variety of things, including infections, in­flam­mation, hepatitis, connective tissue diseases, etc. I'm not positive, but I believe that both IgG and IgA can increase as a result of one of these conditions. In any case, the patient's doctor would be better suited to comment on this.

However, I believe the more important aspect of these test results is the finding that there is monoclonal IgM kappa present in the patient's blood. The presence of monoclonal IgM in any quantity is not normal and can possibly signify a variety of conditions. Given this finding, I would suggest you seek out a myeloma specialist who can help determine the cause of the monoclonal IgM. That specialist should also be able address the increased IgG and IgA levels (which may be unrelated to the presence of the monoclonal IgM). See this thread for various possibilities associated with monoclonal IgM:

https://myelomabeacon.org/forum/just-beginning-the-journey-t6416.html#p38197

If you let us know what city the patient is in, folks on this site can make some recommendations as to where to find nearby myeloma specialists.

[rosas]

Re: Can IgG and IgA increase together at the same time?

by rosas on Wed Dec 16, 2015 10:34 pm

Hi there,

Thank you for your reply. We are on Boston. Any recommendations are great. We would prefer to go to Tufts or MGH if you have recommendations for there.

Thank you again.

[Multibilly]

Re: Can IgG and IgA increase together at the same time?

by Multibilly on Thu Dec 17, 2015 9:22 am

Boston is probably one of the best cities in the USA to see multiple myeloma specialists. Dana Farber has some of the top multiple myeloma specialists in the world. Dr. Noopur Raje at MGH is also a top notch specialist and researcher in the field of multiple myeloma.

[Cheryl G]

Re: Can IgG and IgA increase together at the same time?

by Cheryl G on Thu Dec 17, 2015 9:34 am

As Multibilly mentioned, Dana Farber has many top notch myeloma specialists, and Dr. Raje and Dr. Andrew Yee are at MGH.

I'd also add that Dr. Raymond Comenzo is at Tufts, if that is more convenient for you for any reason. Dr. Comenzo was formerly at Sloan-Kettering and specializes in plasma cell disorders, including MGUS, multiple myeloma, and amyloidosis.

Good luck!