[CB2503]

IgA Kappa. Quant IgA: 335, m-spike: 0.4?

by CB2503 on Tue Apr 07, 2015 4:19 pm

Hello everyone

My wife was diagnosed with MGUS IgA Kappa a year ago with a total IgA quant of 336 mg/dL. IFE confirmed IgA K.

A year later, and at a different lab, her quant IgA came back at 335 mg/dL, but SPEP came back with "2 small peaks of 0.2 each in the fast gamma region". IFE shows IgA K + IgA K.

Am I right to assume that total quant IgA is a better indicator than the SPEP in this case given that IgA can migrate? In our case clearly the SPEP is overestimating the m-spike values which would add up to more than her total IgA?

Her true m-spike then cannot exceed 0.335 - 0.085 (min range new lab) = 0.25, or 250 mg/dL?

Thank you!

[Multibilly]

Re: IgA Kappa. Quant IgA: 335, m-spike: 0.4?

by Multibilly on Tue Apr 07, 2015 5:06 pm

CB2503,

You may find that these discussions will help you sort this out:

https://myelomabeacon.org/forum/iga-multiple-myeloma-how-to-monitor-t2775.html
https://myelomabeacon.org/forum/iga-and-m-spike-t4563.html