Approximately eight months after a stem cell transplant for treatment of Ig(D) multiple myeloma (lambda), my kappa and lambda serum free light chain values, as well as the K/L ratio, remains quite low. Kappa values < 0.02 mg/dl, lambda values ~ 0.3 mg/l and a ratio < 0.1. The serum Ig(D), A, M and G values are also well below normal. Could anyone provide me information of what I may expect regarding the serum free light chain concentrations in the future? At some point will they increase closer to a normal range and remain for awhile? What time frame would be involved?
Thanks for any help.
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Re: Hypogammaglobulinemia after stem cell transplant
The immune suppression that occurs after high dose therapy and a stem cell transplant is profound and can often last up to a year or more. Assuming your disease in in remission however, I would expect that your normal B cells and plasma cells should be recovering over the next few months, such that your free light chains and immunoglobulins should start increasing toward the normal range by a year post-stem cell transplant, though they may continue to remain somewhat subnormal for several months thereafter. One year post-stem cell transplant is when we usually start re-introducing childhood and other immunizations.
Hope this helps!
Hope this helps!
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Dr. Adam Cohen - Name: Adam D. Cohen, M.D.
Beacon Medical Advisor
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