My husband was treated with 4 cycles of bortezomib (Velcade), lenalidomide (Revlimid), and dexamethasone. He is off all drugs except acyclovir and trimethoprim-sulfamethoxazole (Bactrim) since 15 days now for prevention. He has been taking atorvastatin (Lipitor) 5 mg since 3 months, as his lipids were high.
The latest lipid profile shows that all lipids have further gone up markedly. Any explanations anyone?
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Re: High lipid levels after completing treatment
Hello nbijli,
Have you spoken to your husband's doctor about the lipid levels? If so, what did he/she say?
I'm definitely NOT a doctor, but I wonder if the increasing lipid levels may be a sign that something is going on with your husband's kidneys. As I understand, a decrease in kidney function can cause lipid levels to increase.
Does your husband have his blood creatinine and urea nitrogen (BUN) checked regularly? If so, have there been any changes in those lab results recently?
I also wondered if perhaps liver function might be playing a role in what you've been seeing with the lipid levels. As I understand it, however, decreased liver function would typically result in reduced, rather than increased, lipid levels. So I don't think that's the source of the problem.
What about your husband's diet? Has it changed at all recently? Has he started eating more food that could cause high lipid levels?
I did find one article,
http://www.ncbi.nlm.nih.gov/pubmed/8754625
that suggests the antibiotic combination your husband is taking caused some lipid levels to be elevated in laboratory animals. But this doesn't seem to be a generally accepted side effect of the drug combination. It's not mentioned, for example, in the prescribing information for the drug combination.
Have you spoken to your husband's doctor about the lipid levels? If so, what did he/she say?
I'm definitely NOT a doctor, but I wonder if the increasing lipid levels may be a sign that something is going on with your husband's kidneys. As I understand, a decrease in kidney function can cause lipid levels to increase.
Does your husband have his blood creatinine and urea nitrogen (BUN) checked regularly? If so, have there been any changes in those lab results recently?
I also wondered if perhaps liver function might be playing a role in what you've been seeing with the lipid levels. As I understand it, however, decreased liver function would typically result in reduced, rather than increased, lipid levels. So I don't think that's the source of the problem.
What about your husband's diet? Has it changed at all recently? Has he started eating more food that could cause high lipid levels?
I did find one article,
http://www.ncbi.nlm.nih.gov/pubmed/8754625
that suggests the antibiotic combination your husband is taking caused some lipid levels to be elevated in laboratory animals. But this doesn't seem to be a generally accepted side effect of the drug combination. It's not mentioned, for example, in the prescribing information for the drug combination.
2 posts
• Page 1 of 1