[Multibilly]

Re: High kappa-lambda ratio due to low lambda level

by Multibilly on Tue Mar 29, 2016 10:15 am

Niki,

I'm at a loss to comment. Maybe some others on the forum have been through this sort of thing themselves.

[JimNY]

Re: High kappa-lambda ratio due to low lambda level

by JimNY on Tue Mar 29, 2016 10:59 am

Hi Niki and Multibilly,

Is it possible that the test results Niki got are showing that she has

1. Signs of a light-chain only clone, i.e., a clone that throws off only monoclonal kappa light chains, rather than throwing off complete immunoglobulins and excess free light chains, and
2. The kappa light-chain only clone is present to just a limited extent, so it is not causing an above-normal kappa free light chain level?

Recall that the serum free light chain test measures both healthy and monoclonal free light chains.

[Multibilly]

Re: High kappa-lambda ratio due to low lambda level

by Multibilly on Tue Mar 29, 2016 3:34 pm

Jim,

I was sort of thinking along your same lines, but I wasn't entirely sure of myself.

Niki,

Did your serum protein electrophoresis test (not the serum immunofixation test) measure any sort of a serum M-spike?

[Niki]

Re: High kappa-lambda ratio due to low lambda level

by Niki on Tue Mar 29, 2016 5:26 pm

The serum protein electro­phoresis test is negative for M-spike, fortunately. Otherwise the oncolo­gist would be sure that this is a relapse. He is still thinking about it due to the negative bone marrow biopsy and a negative minimal residual disease test that I had in July.

He believes that the findings are associated with some infections that I had lately, but who knows, time will tell.

[Multibilly]

Re: High kappa-lambda ratio due to low lambda level

by Multibilly on Tue Mar 29, 2016 5:37 pm

Indeed, time will tell ... such is the nature of this beast.