[Ravi2012]

High Igm, kappa and an abnormality in rib bone scan

by Ravi2012 on Thu Feb 28, 2013 5:33 pm

Hi, I am a 30 yrs old man. I got exposed to toxic chemical fumes (possible carcinogens) for 30min ~ 4 months ago. I developed (a) frontal (forehead and temple area) headache all the time and (b) pain on the rib wall. It started on the front right rib but now has spread to both side (c) Recently I started having numbness feeling in my hand fingers. (d) Have had few drops of blood in the dry nasal mucus from right nostril few times, or trace of blood when I blow my nose sometimes.

Abnormal Blood work: High Igm (497 (Lab max. 230)), Elevated Gamma Globulin (1.7 (Lab max. 1.6). Increased polyclonal immunoglobulins. My free light chain kappa appears increased (2.41, (Lab max. 0.33-1.94), but lambda is w/in the range (1.94 (Lab max. 0.57-2.63), and kappa/ lambda is w/in range (1.24, (Lab max. 0.26-1.65)).

Recently had a nuclear bonescan and it showed an abnormality in the 7th rib near posterior axillary line on right side; but Dr. orderd a follow-up x-ray and said that Xray didn't show anything on that spot, so that abnormality could be due to some injury I may have in the past (however I never ever had any injury). By saying that polyclonal is benign Dr sent me home.

Normal Blood work: CBC, CMP, ESR, CRP, CK, Vit D, Vat B12,Diabetese, Hep. A/B/C, Complement 3 &4, Rhematoid factor, ANA, LACTATE DEHYDROGENASE, DNA AUTOABS DOUBLE STRANDED, SCLERODERMA ANTIBODY SCL 70, ENA ANTIBODIES (SM AND SM/RNP). All came normal

Eco, Lungs CT, Head CT and Head MRI, Chest Xray. They all came normal.

If I search on the web for high Igm and kappa, I am getting links for Myloma, and WM. Dr. said that I have polyclonal gamma globulin so I don’t have them, but I wonder if I can still have these disease even Igm is polyclonal? My symptoms are persistent so I know there is something wrong causing high Igm. Any suggestion for any test to rule out these serious disease?, or what could be wrong which can cuase high Igm? I was very healthy since last 8 years and never had any health issues until this chemical inhalation. Thanks very much. Regards.