[Lrthorpe1]

6-year-old with high IgE, low lambda free light chain

by Lrthorpe1 on Wed May 11, 2016 3:41 pm

Hello,

My 6 year old son has been sick since January with severe nausea, appetite loss, on and off fevers, leg pain, fatigue and severe pallor. His pediatrician sent us to hematology when she discovered anemia, elevated IgE levels (2475) and eosinophilia (1200).

The hematologist ran electrophoresis which came back saying, "evaluation reveals one faint restricted band migrating in the gamma region which was of too low a concentration to definitively identify."

The lambda light chain free, serum, was low at 3.7 and the kappa lambda ratio was high at 2.41.

They said that doesn't mean anything and is only concerning when the free serum is high. Meanwhile, he started having blood in his urine, which prompted a nephrology evaluation and 24-hour urine collection which showed high protein, high creatinine, and low calcium.

The doctors keep saying that it must be an autoimmune recess or immune dysfunction, yet all antibody labs as normal.

He also had an endoscopy due to nausea and it came back showing eosinophils in his mid esophagus and reactive changes signifying reflux.

Does this mean anything to you guys? We just want to know what is going on so we can help him.

Thank you,
Lauren

[Multibilly]

Re: 6-year-old with high IgE, low lambda free light chain

by Multibilly on Wed May 11, 2016 5:05 pm

Sorry to hear about your 6-year old.

The good news is that it is incredibly unlikely to be myeloma given his age and the fact that his IgE is the immunoglobulin that is elevated.

I might suggest poking around this website and typing in "elevated IgE" and/or "elevated IgE eosinophilia" in their search engine. They also appear to have an "ask the expert" function on their site.