Hello,
I am a 41-year-old female and haven't been well for over a year now and am looking for some clarification please.
I have joint swelling in hands and feet, red flush face (we thought it was the lupus butterfly rash),
my
eGFR is 67,
IgA is 5.29 g/L (high),
Erythrocyte sedimentation rate (ESR) is 33 multiple myeloma/HR(high)
RBC 3.79 xE12/L (low)
Hemoglobin is 118 g/l (low)
C-reactive protein (CRP) is 18 mg/l (high)
and an ill defined band in the front gamma globulin region was detected and beta gamma bridging was observed (beta 2 globulin was 5.1 g/l).
An immunofixation revealed that no monoclonal band was detected in serum.
I have had a kidney biopsy and so do not have lupus or IgA nephropathy. I was diagnosed with disk degenerative disease with a bulge at L5 and S1 touching both nerves bilaterally.
I am anxious to figure out what could be causing the decreased kidney function and was wondering about multiple myeloma? Only my IgA is high, which could mean multiple myeloma, however since no monoclonal band was detected, does that mean it is impossible to have multiple myeloma? Can IgA be an intact globulin with no type?
Any help would be appreciated! Thank you!
Forums
2 posts
• Page 1 of 1
Re: High IgA, low eGFR & hemoglobin, but no monoclonal band
Hi Kim,
The fact that your IgA has no apparent monoclonal bands certainly points in the direction of you not having myeloma. In my case I had an IgA level of 44 g/L with 40 g/L being clonal before I was diagnosed with myeloma via a bone marrow biopsy. The definite diagnosis came from the fact that 50% of the cells in my bone marrow were cancerous plasma cells.
I’m not sure I understand your second question. Plasma cells produce the immunoglobulins (complex protein molecules). It turns out that there are various types of immunoglobulins, with the major groups being designated IgA, IgB, IgM, and others. There are also minor groupings.
So is it possible for a cancerous plasma cell to be so far from being a normal plasma cell that it produces immunoglobulins which are so different that they are not recognized as being an immunoglobulin? That is a very good question. One for the experts. Is that your second question?
I hope your doctors get to the bottom of your symptoms.
Good luck,
Joe
The fact that your IgA has no apparent monoclonal bands certainly points in the direction of you not having myeloma. In my case I had an IgA level of 44 g/L with 40 g/L being clonal before I was diagnosed with myeloma via a bone marrow biopsy. The definite diagnosis came from the fact that 50% of the cells in my bone marrow were cancerous plasma cells.
I’m not sure I understand your second question. Plasma cells produce the immunoglobulins (complex protein molecules). It turns out that there are various types of immunoglobulins, with the major groups being designated IgA, IgB, IgM, and others. There are also minor groupings.
So is it possible for a cancerous plasma cell to be so far from being a normal plasma cell that it produces immunoglobulins which are so different that they are not recognized as being an immunoglobulin? That is a very good question. One for the experts. Is that your second question?
I hope your doctors get to the bottom of your symptoms.
Good luck,
Joe
-
Wobbles - Name: Joe
- Who do you know with myeloma?: myself
- When were you/they diagnosed?: June 2016
- Age at diagnosis: 67
2 posts
• Page 1 of 1