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Questions and discussion about monoclonal gammopathy of undetermined significance (i.e., diagnosis, risk of progression, living with the disease, etc.)

Have MGUS, wondering if my labs indicate progression to multiple myeloma

by lhuntd on Thu Dec 27, 2012 4:38 pm

Hi, I am new to this forum. My hx is that I have had Lupus for about 20 yrs now. I also have Sjogrens, hypothyroidism, and mitral valve pro lasp. I was recently diagnosed with MGUS (3 yrs). I also had idiopathic thrombocytopenia in 1996.
My rheumatologist found an abnormal blood protein in blood work. Last year my blood work came back with the following results. (only abnormal results) I have put this years results next to last years.

CBC 2011 / 2012

RBC LOW 3.90 / 3.99
MCH HIGH 32.8 / 32.9
RDW LOW 10.7 / 11.1
NEU% HIGH 73.5 / 81.7
LY% LOW 18.6 / 11.2
NEU% ANC HIGH 4.1 / 5.9
LY% LOW 1.0 / 0.8
PLT NORMAL 289 / 305
CALCIUM HIGH 10.5 / 10.4


LDH 196 / 166

BETA 2 MICROGOBULIN HIGH 2.93 / NOT DONE
IgG quant 822 / 594 low
IgA,quant low 47 / 30
IgM quant high 601 / 359
monoclonal spike high 0.4 / 0.3
kappa light chain free high 37.0 / 41.8
lamba light chain 10.9 / 6.6
free k/l ratio high 3.39 / 6.33

other tests
total protein 7.6 / 6.8
albumin, spe 4.5 / 4.2
alpha 1 globulin 0.3 / 0.2
alpha 2 globulin 0.8 / 0.8
beta globulin 0.9 / 0.9
gamma globulin 1.1 / 0.7

I am thinking of getting a second opinion, for the fact that my current doctor has not told me any thing and does not seem concerned. My question of anyone out there is, does this years lab results looks like i could possibly changing status from MGUS to myeloma. The reason for my concern is that my dad died of ambloidoisis and my mom died of hemolytic anemia. I do not want to wait until the last minute to start preventative treatment.

lhuntd
Name: Emily
Who do you know with myeloma?: Me-MGUS x 3 years
When were you/they diagnosed?: 3 years ago
Age at diagnosis: 53

Re: Have MGUS, wondering if my labs indicate progression to

by MissMolly on Wed Jan 02, 2013 12:17 pm

Have you had a bone marrow biopsy? If so, what are the results?

MissMolly
Who do you know with myeloma?: Self; Grandfather died from multiple myeloma
When were you/they diagnosed?: April 2011 MGUS; July 2012 SMM
Age at diagnosis: 49


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