I'm curious and can't find anything about my hubby's gain of chromosome 9, 15 and CCND1 / 11q13 from his FISH report. The onc said the interpretation was 'good', putting him in standard category. I kinda understand a deletion or translocation, but how does a gain effect someone?
If helpful: The report stated, One hundred interphase nuclei were examined for each probe and revealed a gain of chromosome 9 in 21.0%, a gain of chromosome 15 in 27.0%, and an extra signal for CCND1/11q13 in 21.0% of nuclei.
There are two pages of info, the second page describing the Methodology in great detail.
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wekebu - Name: Wendy
- Who do you know with myeloma?: Hubby
- When were you/they diagnosed?: Jan 2016
- Age at diagnosis: 55
Re: Gain of chromosome 9 and 15?
Hi Wendy,
When you have a gain of a full chromosome, that is also commonly referred to as a trisomy. So the 9 and 15 gains are considered to be trisomies of chromsomes 9 and 15 (you've basically got three copies each of chromosomes 9 and 15, instead of the usual two). Trisomies of chromosomes 9 and 15 are the top two most common trisomies found in multiple myeloma patients.
In general, trisomies are good things with regard to multiple myeloma prognosis. However, there are gains such as 1q21 that one does need to worry about, but you don't have that particular gain listed in your post.
The way I understand it, is if your CCND1/11q13 probe flagged an extra signal, it is likely because of the result of a translocation involving the IgH gene.
You may want to try and skim through the article mentioned in this post to really understand all this better.
I believe that in your case, the key piece of information from the above article is in Table 4.
"Trisomies plus any one of the IgH translocations = Standard risk of progression, median TTP of 5 years and it may ameliorate adverse prognosis conferred by high-risk IgH translocations and del 17p".
I'm still trying to better understand the fundamentals of multiple myeloma genetics, so I may not be spot on with my above remarks. You should therefore verify all this with your doc.
When you have a gain of a full chromosome, that is also commonly referred to as a trisomy. So the 9 and 15 gains are considered to be trisomies of chromsomes 9 and 15 (you've basically got three copies each of chromosomes 9 and 15, instead of the usual two). Trisomies of chromosomes 9 and 15 are the top two most common trisomies found in multiple myeloma patients.
In general, trisomies are good things with regard to multiple myeloma prognosis. However, there are gains such as 1q21 that one does need to worry about, but you don't have that particular gain listed in your post.
The way I understand it, is if your CCND1/11q13 probe flagged an extra signal, it is likely because of the result of a translocation involving the IgH gene.
You may want to try and skim through the article mentioned in this post to really understand all this better.
I believe that in your case, the key piece of information from the above article is in Table 4.
"Trisomies plus any one of the IgH translocations = Standard risk of progression, median TTP of 5 years and it may ameliorate adverse prognosis conferred by high-risk IgH translocations and del 17p".
I'm still trying to better understand the fundamentals of multiple myeloma genetics, so I may not be spot on with my above remarks. You should therefore verify all this with your doc.
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Multibilly - Name: Multibilly
- Who do you know with myeloma?: Me
- When were you/they diagnosed?: Smoldering, Nov, 2012
Re: Gain of chromosome 9 and 15?
Multibilly,
Your reply is very helpful to many of us. Thank you for all your efforts!
Your reply is very helpful to many of us. Thank you for all your efforts!
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Arizonan - Name: Arizonan
- Who do you know with myeloma?: Self
- When were you/they diagnosed?: April 2010
- Age at diagnosis: 54
Re: Gain of chromosome 9 and 15?
Yes, thank you. I'm still reading through, but wanted to thank you.
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wekebu - Name: Wendy
- Who do you know with myeloma?: Hubby
- When were you/they diagnosed?: Jan 2016
- Age at diagnosis: 55
4 posts
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