My FISH analysis says "Gain of CKS1B (1q21.3) detected in 80% of cells."
Does a "gain of CKS1B (1q21.3)" mean an extra chromosome?
Thank you.
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Re: Gain of CKS1B (1q21.3) - same as extra chromosome?
Not exactly. Keep in mind that chromosomes are made up of genes, and genes are made up of varying lengths of DNA.
This particular notation is telling you that you have multiple extra copies of the CKS1B gene, but not necessarily an entire extra chromosome.
Think of "1q21.3" as being a specific address for a location of a gene on a specific part of a chromosome.
In this case, the CKS1B gene is located in the 3rd band of the 21st segment of the long arm ("q" means the long arm as opposed to the "p" short arm) of chromosome 1. The fact that you have a CKS1B gain (also known as "amplification"), means that you have multiple extra copies of that gene at that chromosomal address.
You would want to look for a term such as "hyperdiploidy" or "trisomy" in the section of the report where they report your "karyotype" to see if you had an extra chromosome. Note that 1q gains can often occur as the result of having a trisomy (having an extra chromosome) and / or specific genetic translocations (the swapping of genetic material between chromosomes).
This particular notation is telling you that you have multiple extra copies of the CKS1B gene, but not necessarily an entire extra chromosome.
Think of "1q21.3" as being a specific address for a location of a gene on a specific part of a chromosome.
In this case, the CKS1B gene is located in the 3rd band of the 21st segment of the long arm ("q" means the long arm as opposed to the "p" short arm) of chromosome 1. The fact that you have a CKS1B gain (also known as "amplification"), means that you have multiple extra copies of that gene at that chromosomal address.
You would want to look for a term such as "hyperdiploidy" or "trisomy" in the section of the report where they report your "karyotype" to see if you had an extra chromosome. Note that 1q gains can often occur as the result of having a trisomy (having an extra chromosome) and / or specific genetic translocations (the swapping of genetic material between chromosomes).
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Multibilly - Name: Multibilly
- Who do you know with myeloma?: Me
- When were you/they diagnosed?: Smoldering, Nov, 2012
Re: Gain of CKS1B (1q21.3) - same as extra chromosome?
Thank you for such a detailed and complete answer.
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jlasiter - Name: jlmtc
3 posts
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