Hello Mike:
Dehydration can be another cause. My hematologist said not to worry about light chain fluctuation of twenty percent or so.
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MMFeb16,15 - Who do you know with myeloma?: Self
- When were you/they diagnosed?: February 16, 2015
- Age at diagnosis: 66
Re: Free light chain fluctuations during treatment
Hi Mike and MMFeb16,15:
Both of you pointed out very important causes of these kappa fluctuations, as I was getting my monthly (every 4 weeks, to be exact) kappa and kappa / lambda readings!
I just got my readings of
kappa = 33.1 (last reading 33.2), and
kappa / lambda = 1.49 (the last reading of 1.6).
My kappa / lambda shows a substantial improvement. When the recent flare up of allergic reaction (my EOS reading is at the high end of 6, from the past lower levels) is taken into account, both the kappa and lambda rising MAY indicate that almost 20% of the rise in both these parameters is due to these allergies (runny nose, too). Not too bad if I can manage to play at least a round of golf every week. It's hard to wear a face mask all the time, though. I try to avoid being exposed to high winds.
Also, I do not know if there was any impact of the timing of this blood test. I am in the middle of my 3 weeks on of the daily 10 mg Revlimid after switching from the 15 mg every alternate day. The next reading would have the effect, if any, of the 1-week off.
Any thoughts?
K_Shash
Both of you pointed out very important causes of these kappa fluctuations, as I was getting my monthly (every 4 weeks, to be exact) kappa and kappa / lambda readings!
I just got my readings of
kappa = 33.1 (last reading 33.2), and
kappa / lambda = 1.49 (the last reading of 1.6).
My kappa / lambda shows a substantial improvement. When the recent flare up of allergic reaction (my EOS reading is at the high end of 6, from the past lower levels) is taken into account, both the kappa and lambda rising MAY indicate that almost 20% of the rise in both these parameters is due to these allergies (runny nose, too). Not too bad if I can manage to play at least a round of golf every week. It's hard to wear a face mask all the time, though. I try to avoid being exposed to high winds.
Also, I do not know if there was any impact of the timing of this blood test. I am in the middle of my 3 weeks on of the daily 10 mg Revlimid after switching from the 15 mg every alternate day. The next reading would have the effect, if any, of the 1-week off.
Any thoughts?
K_Shash
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K_Shash - Name: K_Shash
- Who do you know with myeloma?: Self
- When were you/they diagnosed?: November 2014
- Age at diagnosis: 67
Re: Free light chain fluctuations during treatment
After treatment (ended June last year), my (involved) lambda flc rose by 60% between November and January - rather worrying - until it then fell back 20% in February and again in March. Almost certainly explained by natural fluctuations and lab measurement variations.
Best regards,
David
Best regards,
David
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Davidg - Name: David
- When were you/they diagnosed?: Feb 2015 - AL Amyloidosis
- Age at diagnosis: 53
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