[Helen521]

FISH results - do they show t(4;14) and t(14;16)?

by Helen521 on Tue Sep 20, 2016 6:22 pm

I have a question regarding my father's FISH results. They read:

An abnormal FISH signal pattern of 2R3G was observed in t(4;14) probe set. This finding is consistent with an IGH gene rearrangement to an unidentified gene that is not FGFR3.

An abnormal FISH signal pattern of 2R3G was observed in t(14;16). This finding is consistent with an IGH rearrangment to an unidentified gene that is not MAF.

Duplication of 1q in 72.3% of nuclei.

The 11;14 probe set showed an abnormal signal pattern (2R3G) displaying an extra copy of the IGH locus suggestive of trisomy/hyperdiploidy of chromosome 14 or IGH gene rearrangement with an unidentified chromosomal partner. This is an abnormal result but NEGATIVE for CCND1/IGH fusion.

Does this mean there is a translocation 4,14 and also a translocation 14,16 -- i.e., t(4;14) and t(14;16)?