Hi All-
In my prior post Boris suggested I look at the results of the FISH assessment. I requested the test from the dr and these were the findings. I am now more worried than ever as from my understanding it shows deletion 13q and p53 gene. Am I reading this correctly? Can anyone please help me interpret this test? If this is true, is there any way I can beat this?
Diagnostic Interpretation:
Analyzable metaphases were not available for karyotype analysis, which may be due to insufficient number of cells received for the test. FISH evaluation did not reveal 1p36 deletion or extra copies of 1q25, a t (4;14), multiple copies of the MLL gene, deletion of the ETV6 (12p13) gene, deletion 13q or monosomy 13, deletion of the CBFB (16q22) gene or loss of the p53 gene in any of the interphase cells examined.
-Sunshine
Forums
6 posts
• Page 1 of 1
Re: FISH Interpretation- Help
Hello.
I think you have misinterpreted the report. Thank you for providing it verbatim.
Your FISH results are normal. There is no evidence of a finding which predicts an adverse prognosis. This is good news !
I think you have misinterpreted the report. Thank you for providing it verbatim.
Your FISH results are normal. There is no evidence of a finding which predicts an adverse prognosis. This is good news !
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Dr. Edward Libby - Name: Edward Libby, M.D.
Beacon Medical Advisor
Re: FISH Interpretation- Help
Dr. Libby you are amazing. THANK YOU SO MUCH for your response, although I am a bit confused. On Monday I met with a new doctor regarding the Carfilzomib clinical trial (56mg/m2). The doctor mentioned to me that I had a very aggressive form of myeloma per the cytogenetic testing. This prompted me to request a copy of the test. When I read the results and saw deletion 13q and gene or loss of p53 gene I became very worried as I have read that these chromosomal abnormalities put a patient in the high-risk group. I will have to ask the doctor what chromosomal abnormalities he was referring to as this is the lastest FISH tests I have.
Again- thank you so much Dr. Libby.
Sunshine!!
Again- thank you so much Dr. Libby.
Sunshine!!
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sunshine15 - When were you/they diagnosed?: 2007
- Age at diagnosis: 49
Re: FISH Interpretation- Help
You are welcome. But, please ask the doctor to list exactly what cytogenetic finding(s) you have and ask them to write it down. Also if you have the report please double check to make sure what you put on your posting was EXACTLY verbatim and correct. I dont want to misinform you and if your doctors are saying you have aggresive disease based on the cytogenetics I am a ittle woried that we dont have all of the information. Some patients have asked for a copy of their cytogenetics report and even post the results on the Forum to help us to understand the underlying findings.
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Dr. Edward Libby - Name: Edward Libby, M.D.
Beacon Medical Advisor
Re: FISH Interpretation- Help
Good Morning All-
Dr. Libby- attached is a copy of the FISH report of my bone marrow biopsy. Aside from the bone marrow biopsy would there be any other tests that were done that would singal an abnormality?
Today I start the Carfilzomib. I will let you all know how I do on the drug. The drug will be administered on days 1,2,8,9,15,16. Hopefully this new drug will help me and others battle myeloma!
-Sunshine
Dr. Libby- attached is a copy of the FISH report of my bone marrow biopsy. Aside from the bone marrow biopsy would there be any other tests that were done that would singal an abnormality?
Today I start the Carfilzomib. I will let you all know how I do on the drug. The drug will be administered on days 1,2,8,9,15,16. Hopefully this new drug will help me and others battle myeloma!
-Sunshine
- Attachments
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FISH Report.pdf- FISH Report
- (32.58 KiB) Downloaded 149 times
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sunshine15 - When were you/they diagnosed?: 2007
- Age at diagnosis: 49
Re: FISH Interpretation- Help
Hello again.
Thank you for the report.
My reading of this is that you do not have high or intermediate risk cytogenetics by FISH. Your results do not demonstrate Del17P, t(14;16), t(14;20) or t(4;14). A standard karyotype could not be done (this is a common finding and does not compromise our conclusions). I often refer to the Mayo Clinic consensus guidelines for a risk classification schema. By their classification you have standard risk.
On the other hand I reviewed the history you posted a few weeks ago and see that you were diagnosed 4 years ago and have received 3-4 lines of treatment. Over time and after multiple relapses the disease becomes more resistant. That would tend to explain why it is becoming difficult to control your myeloma. Carfilzomib is an excellent drug for you to be on at this point in your course. Hopefully you will respond well and potentially follow it with a transplant .
Thank you for sharing your story
Thank you for the report.
My reading of this is that you do not have high or intermediate risk cytogenetics by FISH. Your results do not demonstrate Del17P, t(14;16), t(14;20) or t(4;14). A standard karyotype could not be done (this is a common finding and does not compromise our conclusions). I often refer to the Mayo Clinic consensus guidelines for a risk classification schema. By their classification you have standard risk.
On the other hand I reviewed the history you posted a few weeks ago and see that you were diagnosed 4 years ago and have received 3-4 lines of treatment. Over time and after multiple relapses the disease becomes more resistant. That would tend to explain why it is becoming difficult to control your myeloma. Carfilzomib is an excellent drug for you to be on at this point in your course. Hopefully you will respond well and potentially follow it with a transplant .
Thank you for sharing your story
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Dr. Edward Libby - Name: Edward Libby, M.D.
Beacon Medical Advisor
6 posts
• Page 1 of 1