[dishevelled]

FISH and more????

by dishevelled on Sun Apr 28, 2013 3:01 pm

Can anyone help me understand this? I have smoldering

1q addition, t4;14, del 13q

Does this mean high risk for progression?

Also the BMB showed 10-15% PC however, the immunostaining highlights an area with a large cluster of CD138-positive cells

[Multibilly]

Re: FISH and more????

by Multibilly on Mon Apr 29, 2013 5:48 pm

Hey Heather,

Has your doctor discussed the prognostic impact of your genetic tests with you? Based on only the info you provided and the info in the links below, a t(4;14) translocation would put you in a higher-risk-for-progression category. The 1q gain and 13q deletion often accompanies the t(4;14) translocation.

You should really VERIFY all this with your doc and hopefully a doc that monitors this site will also chime in.

It is also important to remember the quote from Dr. Rajkumar in the third link below: “Patients with t(4;14) and del(17p) need to be followed more closely,” Dr. Rajkumar told The Beacon. “Clearly, not every patient with these abnormalities will progress early, but the risk of progression is higher,” he added.

http://www.cancer.gov/cancertopics/pdq/treatment/myeloma/healthprofessional/page2

http://www.ncbi.nlm.nih.gov/pubmed/21356186

https://myelomabeacon.org/news/2013/03/29/chromosomal-abnormalities-smoldering-myeloma-high-risk-progression/