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FGFR3 overexpression and t(4,14)
Is it possible to have FGFR3 overexpression in the absence of a (4, 14) translocation? Or, does FGFR3 overexpression typically predict this translocation. Thanks!
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WholeNotherWorld - Who do you know with myeloma?: my husband
- When were you/they diagnosed?: Dec. 2016
- Age at diagnosis: 67
Re: FGFR3 overexpression and t(4,14)
Are you saying that you had an iFISH test that showed you had an FGFR3 mutation and/or an immunochemistry test to detect FGFR3 overexpression, but no t(4,14) translocation was detected via iFISH?
There are several papers you can easily find on the web that state that the majority of t(4,14) translocations are accompanied by FGFR3 overexpression. However, the papers don't really comment on the reverse (i.e. what percentage of myeloma patients with FGFR3 overexpression have t(4,14) transloactions).
There are several papers you can easily find on the web that state that the majority of t(4,14) translocations are accompanied by FGFR3 overexpression. However, the papers don't really comment on the reverse (i.e. what percentage of myeloma patients with FGFR3 overexpression have t(4,14) transloactions).
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Multibilly - Name: Multibilly
- Who do you know with myeloma?: Me
- When were you/they diagnosed?: Smoldering, Nov, 2012
Re: FGFR3 overexpression and t(4,14)
Thank you Multibilly.
The exact language of the report we got was
"gain of the CCND1 gene on 11q found in 56.4 % of cells, and gain of the FGFR3 gene A [with a carrot on top] on 4p was found in 61% of cells."
The report never names a specific translocation, but this smells like a translocation to me, but I don't understand it well enough to draw that conclusion. I thought overexpression of CCND1 was related to t(11;14) and FGFR3 was related to t(4;14).
The exact language of the report we got was
"gain of the CCND1 gene on 11q found in 56.4 % of cells, and gain of the FGFR3 gene A [with a carrot on top] on 4p was found in 61% of cells."
The report never names a specific translocation, but this smells like a translocation to me, but I don't understand it well enough to draw that conclusion. I thought overexpression of CCND1 was related to t(11;14) and FGFR3 was related to t(4;14).
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WholeNotherWorld - Who do you know with myeloma?: my husband
- When were you/they diagnosed?: Dec. 2016
- Age at diagnosis: 67
Re: FGFR3 overexpression and t(4,14)
What was the actual test whose results you are looking at? Was it an iFISH test?
In an iFISH test, there are specific probes that look for specific translocations and other mutations that are found and can have an impact on a myeloma patient. It's my understanding that if the iFISH test detects an anomaly in the IGH (immunoglobulin heavy) region on a myeloma patient, that the lab will typically "reflex" (i.e., do a second test) to specifically look for IGH/FGFR3 t(4;14) and IGH/CCND1 t(11;14) translocations, unless the iFISH test is already set up to look for these translocations in the first place. However, to be sure that these specific translocation probes were included in the overall test, you would really need to look at a summary of the probes that were used in the test.
Also, note that you would not have both t(11;14) and t(4;14) translocations present at the same time (see the article discussed in this forum thread for an explanation of why this is the case).
If you had an iFISH test and any translocations were found, they would most likely be noted.
In any case, I'd really suggest chatting with your oncologist to see what these test results actually mean for your situation. Please let us know what you find out.
In an iFISH test, there are specific probes that look for specific translocations and other mutations that are found and can have an impact on a myeloma patient. It's my understanding that if the iFISH test detects an anomaly in the IGH (immunoglobulin heavy) region on a myeloma patient, that the lab will typically "reflex" (i.e., do a second test) to specifically look for IGH/FGFR3 t(4;14) and IGH/CCND1 t(11;14) translocations, unless the iFISH test is already set up to look for these translocations in the first place. However, to be sure that these specific translocation probes were included in the overall test, you would really need to look at a summary of the probes that were used in the test.
Also, note that you would not have both t(11;14) and t(4;14) translocations present at the same time (see the article discussed in this forum thread for an explanation of why this is the case).
If you had an iFISH test and any translocations were found, they would most likely be noted.
In any case, I'd really suggest chatting with your oncologist to see what these test results actually mean for your situation. Please let us know what you find out.
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Multibilly - Name: Multibilly
- Who do you know with myeloma?: Me
- When were you/they diagnosed?: Smoldering, Nov, 2012
Re: FGFR3 overexpression and t(4,14)
Multibilly,
Thank you for your input.
The test results just reference FISH, not iFISH. IgH rearrangement was found in 45% of cells. We understand that there cannot be concurrent 11;14 AND 4;14 translocations. The doctor (a myeloma specialist) did indicate that there had been a clonal progression from the prior bone marrow of nearly 3 years ago, although he did not explain the results to answer our question (which, in reality, didn't develop until after the appointment and some additional Internet research).
My husband is now receiving treatment as part of a clinical trial. We do have an appointment with the physician on December 23, and he knows the questions we are asking, so, presumably we'll understand all this better on that date.
I'll let you know what we find out.
Thank you for your input.
The test results just reference FISH, not iFISH. IgH rearrangement was found in 45% of cells. We understand that there cannot be concurrent 11;14 AND 4;14 translocations. The doctor (a myeloma specialist) did indicate that there had been a clonal progression from the prior bone marrow of nearly 3 years ago, although he did not explain the results to answer our question (which, in reality, didn't develop until after the appointment and some additional Internet research).
My husband is now receiving treatment as part of a clinical trial. We do have an appointment with the physician on December 23, and he knows the questions we are asking, so, presumably we'll understand all this better on that date.
I'll let you know what we find out.
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WholeNotherWorld - Who do you know with myeloma?: my husband
- When were you/they diagnosed?: Dec. 2016
- Age at diagnosis: 67
Re: FGFR3 overexpression and t(4,14)
Hello,
In April 2014, I had a myelogram (the only one I received). There was "evidence of a t (4; 14) WITHOUT increased expression of FGFR3."
I am classified as asymptomatic myeloma (there were only 3% plasma cells but most of them dystrophic), but since then I have only had routine blood tests. Increases in gamma globulin but is rather stable.
Jacqueline
(France)
In April 2014, I had a myelogram (the only one I received). There was "evidence of a t (4; 14) WITHOUT increased expression of FGFR3."
I am classified as asymptomatic myeloma (there were only 3% plasma cells but most of them dystrophic), but since then I have only had routine blood tests. Increases in gamma globulin but is rather stable.
Jacqueline
(France)
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Jacqueline - Name: Jacqueline
- When were you/they diagnosed?: november 2010
- Age at diagnosis: 53
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